Isaeva2008 - Modelling of Anti-Tumour Immune Response Immunocorrective Effect of Weak Centimetre Electromagnetic Waves

  public model
Model Identifier
BIOMD0000000910
Short description 
Modelling of anti-tumour immune response: Immunocorrective effect
of weak centimetre electromagnetic waves
O.G. Isaeva* and V.A. Osipov
Bogoliubov Laboratory of Theoretical Physics, Joint Institute for Nuclear Research, Dubna,
Moscow Region, Russia

We formulate the dynamical model for the anti-tumour immune response based on
intercellular cytokine-mediated interactions with the interleukin-2 (IL-2) taken into
account. The analysis shows that the expression level of tumour antigens on antigen
presenting cells has a distinct influence on the tumour dynamics. At low antigen
presentation, a progressive tumour growth takes place to the highest possible value.
At high antigen presentation, there is a decrease in tumour size to some value when the
dynamical equilibrium between the tumour and the immune system is reached. In the
case of the medium antigen presentation, both these regimes can be realized depending
on the initial tumour size and the condition of the immune system. A pronounced
immunomodulating effect (the suppression of tumour growth and the normalization of
IL-2 concentration) is established by considering the influence of low-intensity
electromagnetic microwaves as a parametric perturbation of the dynamical system. This
finding is in qualitative agreement with the recent experimental results on
immunocorrective effects of centimetre electromagnetic waves in tumour-bearing mice.
Keywords: carcinogenesis; interleukin-2; modelling; anti-tumour immunity;
electromagnetic waves
Format
SBML (L2V4)
Related Publication
  • Modelling of Anti-Tumour Immune Response: Immunocorrective Effect of Weak Centimetre Electromagnetic Waves
  • O. G. Isaeva and V. A. Osipov
  • Computational and Mathematical Methods in Medicine , 7/ 2008 , Volume 10 , Issue 3 , pages: 185-201 , DOI: 10.1080/17486700802373540
  • Bogoliubov Laboratory of Theoretical Physics, Joint Institute for Nuclear Research, Dubna, Moscow Region, Russia
  • Abstract We formulate the dynamical model for the anti-tumour immune response based on intercellular cytokine-mediated interactions with the interleukin-2 (IL-2) taken into account. The analysis shows that the expression level of tumour antigens on antigen presenting cells has a distinct influence on the tumour dynamics. At low antigen presentation, a progressive tumour growth takes place to the highest possible value. At high antigen presentation, there is a decrease in tumour size to some value when the dynamical equilibrium between the tumour and the immune system is reached. In the case of the medium antigen presentation, both these regimes can be realized depending on the initial tumour size and the condition of the immune system. A pronounced immunomodulating effect (the suppression of tumour growth and the normalization of IL-2 concentration) is established by considering the influence of low-intensity electromagnetic microwaves as a parametric perturbation of the dynamical system. This finding is in qualitative agreement with the recent experimental results on immunocorrective effects of centimetre electromagnetic waves in tumour-bearing mice. Volume 10, Issue 3, Pages 185-201
Contributors
Submitter of the first revision: Mohammad Umer Sharif Shohan
Submitter of this revision: Mohammad Umer Sharif Shohan
Modellers: Mohammad Umer Sharif Shohan

Metadata information

is (2 statements)
BioModels Database BIOMD0000000910
BioModels Database MODEL2001140001

hasTaxon (1 statement)
Taxonomy Homo sapiens

hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model

isDescribedBy (1 statement)
isVersionOf (1 statement)
Curation status
Curated
Modelling approach(es)
ordinary differential equation model
Tags
Immuno-oncology

Connected external resources

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Model files
Isaeva2008.xml SBML L2V4 Isaeva2008 - Modelling of Anti-Tumour Immune Response Immunocorrective Effect of Weak Centimetre Electromagnetic Waves 29.32 KB Preview | Download

Additional files
Isaeva2008.cps COPASI version 4.24 (Build 197) Isaeva2008 - Modelling of Anti-Tumour Immune Response Immunocorrective Effect of Weak Centimetre Electromagnetic Waves 57.61 KB Preview | Download
Isaeva2008.sedml SEDML L1V2 Isaeva2008 - Modelling of Anti-Tumour Immune Response Immunocorrective Effect of Weak Centimetre Electromagnetic Waves 2.65 KB Preview | Download

  • Model originally submitted by : Mohammad Umer Sharif Shohan
  • Submitted: Jan 14, 2020 11:23:39 AM
  • Last Modified: Jan 14, 2020 12:19:58 PM
Revisions
  • Version: 6 public model Download this version
    • Submitted on: Jan 14, 2020 12:19:58 PM
    • Submitted by: Mohammad Umer Sharif Shohan
    • With comment: Automatically added model identifier BIOMD0000000910
  • Version: 4 public model Download this version
    • Submitted on: Jan 14, 2020 11:29:20 AM
    • Submitted by: Mohammad Umer Sharif Shohan
    • With comment: Automatically added model identifier BIOMD0000000910
  • Version: 2 public model Download this version
    • Submitted on: Jan 14, 2020 11:28:21 AM
    • Submitted by: Mohammad Umer Sharif Shohan
    • With comment: Automatically added model identifier BIOMD0000000910
  • Version: 1 public model Download this version
    • Submitted on: Jan 14, 2020 11:23:39 AM
    • Submitted by: Mohammad Umer Sharif Shohan
    • With comment: Import of Isaeva2008 - Modelling of Anti-Tumour Immune Response Immunocorrective Effect of Weak Centimetre Electromagnetic Waves

(*) You might be seeing discontinuous revisions as only public revisions are displayed here. Any private revisions unpublished model revision of this model will only be shown to the submitter and their collaborators.

Legends
: Variable used inside SBML models


Species
Species Initial Concentration/Amount
L

C12543 		240000.0 mmol
I2

Interleukin-2 		3.6E7 mmol
T

Neoplastic Cell 		200000.0 mmol
Reactions
Reactions Rate Parameters
=> L; I2 compartment*(VL+alpha_L*L*I2) VL = 79000.0; alpha_L = 9.9E-9
=> I2; T compartment*alpha_I2*T/(T+K_T) alpha_I2 = 1.25E7; K_T = 52000.0
L => compartment*beta_L*L beta_L = 0.33
T => ; L compartment*(alpha_T*T*ln(beta_T*T/alpha_T)+gama_prime_L*L*T) beta_T = 8.4E-8; alpha_T = 0.22; gama_prime_L = 4.0E-7
I2 => ; L, T compartment*(alpha_bar_L*L*I2+gama_T*T*I2) alpha_bar_L = 6.6E-8; gama_T = 6.6E-7
Curator's comment:
(added: 14 Jan 2020, 11:27:54, updated: 14 Jan 2020, 11:27:54)
The model has been encoded in COPASI 4.24 (Build 197) and the Figure 6 of the publication (without exposure) has been generated using COPASI