Kawka2014 - Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model

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Model Identifier
MODEL1912090002
Short description 
This is a mathematical model of the Wnt signaling pathway in medulloblastoma comprised of two compartments. Composed of nine ordinary differential equations accounts for the formation and dissociation of complexes as well as the transcription, translation and transportation between the cytoplasm and the nucleus.
Format
SBML (L2V4)
Related Publication
  • Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model.
  • Kawka J, Sturm D, Pleier S, Pfister S, Marciniak-Czochra A
  • Journal of theoretical biology , 8/ 2014 , Volume 354 , pages: 105-112 , PubMed ID: 24685888
  • Institute of Applied Mathematics, Interdisciplinary Center for Scientific Computing (IWR) and BIOQUANT, University of Heidelberg, Germany. Electronic address: joanna.kawka@bioquant.uni-hd.de.
  • Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses.
Contributors
Submitter of the first revision: Johannes Meyer
Submitter of this revision: Johannes Meyer
Modellers: Johannes Meyer

Metadata information

hasProperty (2 statements)
Mathematical Modelling Ontology Ordinary differential equation model
Gene Ontology Wnt signaling pathway

Curation status
Non-curated
Modelling approach(es)
ordinary differential equation model
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  • Model originally submitted by : Johannes Meyer
  • Submitted: Dec 9, 2019 2:40:56 PM
  • Last Modified: Dec 9, 2019 2:40:56 PM
Revisions
  • Version: 1 public model Download this version
    • Submitted on: Dec 9, 2019 2:40:56 PM
    • Submitted by: Johannes Meyer
    • With comment: Import of Kawka2014 - Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model