Huang2014 - Systematic modeling for the insulin signaling network mediated by IRS1 and IRS2

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Model Identifier
MODEL1912090001
Short description
This is a mathematical model is which is a combination of systemic models for the insulin signaling network as mediated by insulin receptor substrate (IRS) 1 and 2.
Format
SBML (L2V4)
Related Publication
  • Systematic modeling for the insulin signaling network mediated by IRS(1) and IRS(2).
  • Huang C, Wu M, Du J, Liu D, Chan C
  • Journal of theoretical biology , 8/ 2014 , Volume 355 , pages: 40-52 , PubMed ID: 24703981
  • Department of Mathematics, Michigan State University, East Lansing, MI 48824, United States.
  • The hepatic insulin signaling mediated by insulin receptor substrates IRS1 and IRS2 plays a central role in maintaining glucose homeostasis under different physiological conditions. Although functions of individual components in the signaling network have been extensively studied, our knowledge is still limited with regard to how the signals are integrated and coordinated in the complex network to render their functional roles. In this study, we construct systematic models for the insulin signaling network mediated by IRS1 and IRS2, through the integration of current knowledge in the literature into mathematical models of insulin signaling pathways. We hypothesize that the specificity of the IRS signaling mechanisms emerges from the wiring and kinetics of the entire network. A discrete dynamic model is first constructed to account for the numerous dynamic features in the system, i.e., complex feedback circuits, different regulatory time-scales and cross-talks between pathways. Our simulation shows that the wiring of the network determines different functions of IRS1 and IRS2. We further collate and reconstruct a kinetic model of the network as a system of ordinary differential equations to provide an informative model for predicting phenotypes. A sensitivity analysis is applied to identify essential regulators for the signaling process.
Contributors
Submitter of the first revision: Johannes Meyer
Submitter of this revision: Johannes Meyer
Modellers: Johannes Meyer

Metadata information

hasProperty (2 statements)
Curation status
Non-curated
Modelling approach(es)
ordinary differential equation model
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  • Model originally submitted by : Johannes Meyer
  • Submitted: Dec 9, 2019 1:23:09 PM
  • Last Modified: Dec 9, 2019 1:23:09 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Dec 9, 2019 1:23:09 PM
    • Submitted by: Johannes Meyer
    • With comment: Edited model metadata online.