Bidot2008 - Mathematical modelling of T cell activation kinetics

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Mathematical modeling representing Tcell actiavtion regualtion by TCR, IL2 and other players.
Related Publication
  • Mathematical modeling of T-cell activation kinetic.
  • Bidot C, Gruy F, Haudin CS, El Hentati F, Guy B, Lambert C
  • Journal of computational biology : a journal of computational molecular cell biology , 1/ 2008 , Volume 15 , Issue 1 , pages: 105-128 , PubMed ID: 18271720
  • Ecole Nationale SupĂ©rieure des Mines, Immunology Laboratory, University Hospital of St. Etienne, France.
  • T-cell activation is a crucial step in mounting of the immune response. The dynamics of T-cell receptor (TCR) specific recognition of peptide presented by major histocompatibility complex (MHC) molecule decides the fate of the T cell. Several biochemical interactions interfere resulting in a highly complex mechanism that would be difficult to understand without computer help. The aim of the present study was to define a mathematical model in order to approach the kinetics of monoclonal T-cell-specific activation. The reaction scheme was first described and the model was tested using experimental parameters from the published data. Simulations were concordant with experimental data showing proportional decrease of membrane TCR and production of interleukin-2 (IL-2). Agonist and antagonist peptides induce different levels of intracellular signal that could make the yes or no decision for entry to cell cycle. Different conditions (peptide concentrations, initial TCR density and exogenous IL-2 levels) can be tested. Several parameters are missing for parameters estimation and adjustment before it could be adapted for a polyclonal T-cell reaction model. However, the model should be of interest in setting experiments, simulation of clinical responses and optimization of preventive or therapeutic immunotherapy.
Submitter of the first revision: Krishna Kumar Tiwari
Submitter of this revision: Krishna Kumar Tiwari
Modellers: Krishna Kumar Tiwari

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Bidot2008.xml SBML L2V4 file for Bidot 2008 100.95 KB Preview | Download

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Bidot2008.cps COPASI 4.27 (Build 217) file for Bidot 2008 172.07 KB Preview | Download
Bidot2008.sedml SEDML file for Bidot 2008 1.01 KB Preview | Download

  • Model originally submitted by : Krishna Kumar Tiwari
  • Submitted: Oct 29, 2019 4:52:30 PM
  • Last Modified: Oct 29, 2019 4:52:30 PM
  • Version: 2 public model Download this version
    • Submitted on: Oct 29, 2019 4:52:30 PM
    • Submitted by: Krishna Kumar Tiwari
    • With comment: Edited model metadata online.