Galante2012  B7H1 and a Mathematical Model for Cytotoxic T Cell and Tumor Cell Interaction
Model Identifier
BIOMD0000000812
Short description
This is a mathematical model that describes the interactions between cytotoxic T cells and tumor cells as influenced by B7H1 (PDL1) activity, with a focus on how B7H1 affects cancer cells apoptosis.
Format
SBML
(L2V4)
Related Publication
 B7h1 and a mathematical model for cytotoxic T cell and tumor cell interaction.
 Galante A, Tamada K, Levy D
 Bulletin of mathematical biology , 1/ 2012 , Volume 74 , Issue 1 , pages: 91102 , PubMed ID: 21656310
 Department of Mathematics and Center for Scientific Computation and Mathematical Modeling (CSCAMM), University of Maryland, College Park, MD, 20742, USA. agalante@cscamm.umd.edu
 The surface protein B7H1, also called PDL1 and CD274, is found on carcinomas of the lung, ovary, colon, and melanomas but not on most normal tissues. B7H1 has been experimentally determined to be an antiapoptotic receptor on cancer cells, where B7H1positive cancer cells have been shown to be immune resistant, and in vitro experiments and mouse models have shown that B7H1negative tumor cells are significantly more susceptible to being repressed by the immune system. We derive a new mathematical model for studying the interaction between cytotoxic T cells and tumor cells as affected by B7H1. By integrating experimental data into the model, we isolate the parameters that control the dynamics and obtain insights on the mechanisms that control apoptosis.
Contributors
Submitter of the first revision: Johannes Meyer
Submitter of this revision: Rahuman Sheriff
Modellers: Rahuman Sheriff, Johannes Meyer
Submitter of this revision: Rahuman Sheriff
Modellers: Rahuman Sheriff, Johannes Meyer
Metadata information
is (2 statements)
isDescribedBy (1 statement)
isDerivedFrom (1 statement)
hasProperty (3 statements)
isDescribedBy (1 statement)
isDerivedFrom (1 statement)
hasProperty (3 statements)
Mathematical Modelling Ontology
Ordinary differential equation model
Taxonomy Homo sapiens
Gene Ontology programmed cell death
Taxonomy Homo sapiens
Gene Ontology programmed cell death
Curation status
Curated
Tags
Connected external resources
Name  Description  Size  Actions 

Model files 

Galante2012.xml  SBML L2V4 Representation of Galante2012  B7H1 and a Mathematical Model for Cytotoxic T Cell and Tumor Cell Interaction  45.94 KB  Preview  Download 
Additional files 

Galante2012.cps  COPASI file of Galante2012  B7H1 and a Mathematical Model for Cytotoxic T Cell and Tumor Cell Interaction  75.48 KB  Preview  Download 
Galante2012.sedml  SEDML file of Galante2012  B7H1 and a Mathematical Model for Cytotoxic T Cell and Tumor Cell Interaction  3.43 KB  Preview  Download 
 Model originally submitted by : Johannes Meyer
 Submitted: Sep 16, 2019 10:03:46 AM
 Last Modified: Oct 5, 2021 1:31:51 PM
Revisions

Version: 6
 Submitted on: Oct 5, 2021 1:31:51 PM
 Submitted by: Rahuman Sheriff
 With comment: Automatically added model identifier BIOMD0000000812

Version: 2
 Submitted on: Sep 16, 2019 10:03:46 AM
 Submitted by: Johannes Meyer
 With comment: Automatically added model identifier BIOMD0000000812
(*) You might be seeing discontinuous revisions as only public revisions are displayed here. Any private revisions of this model will only be shown to the submitter and their collaborators.
Legends
: Variable used inside SBML models
: Variable used inside SBML models
Species
Species  Initial Concentration/Amount 

X Complex cytotoxic T cell ; neoplastic cell ; Complex 
0.0 item 
C Cancer Uncomplexed neoplastic cell 
1.0 item 
T ast neoplastic cell 
1.0 item 
P Perforin Perforin 
0.315 item 
E CTL cytotoxic T cell 
1.0 item 
Reactions
Reactions  Rate  Parameters 

X_Complex => C_Cancer_Uncomplexed  compartment*k_2*X_Complex  k_2 = 1.0E4 
=> C_Cancer_Uncomplexed  compartment*k*C_Cancer_Uncomplexed  k = 0.035 
T_ast =>  compartment*k_5*T_ast^2  k_5 = 0.003 
=> P_Perforin; E_CTL, C_Cancer_Uncomplexed  compartment*k_p*E_CTL/((k_m_1+E_CTL)*k_m_2*C_Cancer_Uncomplexed)  k_p = 0.097; k_m_2 = 80.0; k_m_1 = 2.2 
=> T_ast  compartment*k*T_ast  k = 0.035 
C_Cancer_Uncomplexed =>  compartment*k_5*C_Cancer_Uncomplexed^2  k_5 = 0.003 
X_Complex =>  compartment*k_3*X_Complex  k_3 = 1.0E4 
C_Cancer_Uncomplexed => X_Complex; E_CTL  compartment*k_1*C_Cancer_Uncomplexed*E_CTL  k_1 = 1.0E4 
E_CTL = ModelValue_11X_Complex  []  ModelValue_11 = 1.0 
Curator's comment:
(added: 16 Sep 2019, 10:03:23, updated: 16 Sep 2019, 10:03:23)
(added: 16 Sep 2019, 10:03:23, updated: 16 Sep 2019, 10:03:23)
Reproduced plot of Figure 3 (Right Panel) in the original publication. Initial conditions are as indicated in the paper and the figure caption.
Model simulated and plot produced using COPASI 4.24 (Build 197).