Feizabadi2011/1 - immunodeficiency in cancer core model

  public model
Model Identifier
BIOMD0000000760
Short description 
The paper describes a basic model of immune-cancer interaction. 
Created by COPASI 4.25 (Build 207) 

This model is described in the article: 
Modeling the Effects of a Simple Immune System and Immunodeficiency on the Dynamics of Conjointly Growing Tumor and Normal Cells
Mitra Shojania Feizabadi and Tarynn M. Witten
International Journal of Biological Sciences 2011; 7(6):700-707

Abstract: In this paper, we develop a theoretical contribution towards the understanding of the complex behavior of conjoint tumor-normal cell growth under the influence of immuno-chemotheraputic agents under simple immune system response. In particular, we consider a core model for the interaction of tumor cells with the surrounding normal cells. We then add the effects of a simple immune system, and both immune-suppression factors and immuno-chemotherapeutic agents as well. Through a series of numerical simulations, we illustrate that the interdependency of tumor-normal cells, together with choice of drug and the nature of the immunodeficiency, leads to a variety of interesting patterns in the evolution of both the tumor and the normal cell populations.

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Format
SBML (L2V4)
Related Publication
  • Modeling the effects of a simple immune system and immunodeficiency on the dynamics of conjointly growing tumor and normal cells.
  • Feizabadi MS, Witten TM
  • International journal of biological sciences , 1/ 2011 , Volume 7 , Issue 6 , pages: 700-707 , PubMed ID: 21647303
  • Physics Department, Seton Hall University, South Orange, NJ 07079, USA. shojanmi@shu.edu
  • In this paper, we develop a theoretical contribution towards the understanding of the complex behavior of conjoint tumor-normal cell growth under the influence of immuno-chemotherapeutic agents under simple immune system response. In particular, we consider a core model for the interaction of tumor cells with the surrounding normal cells. We then add the effects of a simple immune system, and both immune-suppression factors and immuno-chemotherapeutic agents as well. Through a series of numerical simulations, we illustrate that the interdependency of tumor-normal cells, together with choice of drug and the nature of the immunodeficiency, leads to a variety of interesting patterns in the evolution of both the tumor and the normal cell populations.
Contributors
Submitter of the first revision: Jinghao Men
Submitter of this revision: Krishna Kumar Tiwari
Modellers: Krishna Kumar Tiwari, Jinghao Men

Metadata information

isDescribedBy (1 statement)
PubMed 21647303

hasTaxon (1 statement)
Taxonomy Homo sapiens

hasProperty (2 statements)
Gene Ontology immune response to tumor cell
Mathematical Modelling Ontology Ordinary differential equation model

Curation status
Non-curated
Modelling approach(es)
ordinary differential equation model
Tags
Immuno-oncology

Connected external resources

SBGN view in Newt Editor

Name Description Size Actions

Model files
Feizabadi2011_1.xml SBML L2V4 representation of tumour-immune interaction core model 36.33 KB Preview | Download

Additional files
Feizabadi2011_1.cps CPS file of the model in COPASI 56.27 KB Preview | Download
Feizabadi2011_1.sedml Auto-generated SEDML file 2.62 KB Preview | Download

  • Model originally submitted by : Jinghao Men
  • Submitted: Jul 25, 2019 2:48:25 PM
  • Last Modified: Mar 12, 2021 8:55:41 AM
Revisions
  • Version: 6 public model Download this version
    • Submitted on: Mar 12, 2021 8:55:41 AM
    • Submitted by: Krishna Kumar Tiwari
    • With comment: Updated FunctionDefinition with id `log` with another name to resolve SBML function overlap
  • Version: 5 public model Download this version
    • Submitted on: Jul 25, 2019 3:36:49 PM
    • Submitted by: Jinghao Men
    • With comment: Edited model metadata online.
  • Version: 3 public model Download this version
    • Submitted on: Jul 25, 2019 2:48:25 PM
    • Submitted by: Jinghao Men
    • With comment: Automatically added model identifier BIOMD0000000760

(*) You might be seeing discontinuous revisions as only public revisions are displayed here. Any private revisions unpublished model revision of this model will only be shown to the submitter and their collaborators.

Legends
: Variable used inside SBML models


Species
Species Initial Concentration/Amount
T

malignant cell 		1.0 mmol
N

cell 		1.0 mmol
Reactions
Reactions Rate Parameters
T => ; N tumor_microenvironment*b*r0*N/(r1+N) r0 = 1.0 1; r1 = 1000.0 1; b = 1.0 1
=> N tumor_microenvironment*rn*N*(1-N/kn) rn = 0.4 1; kn = 1000000.0 1
=> T tumor_microenvironment*rt*T*(1-T/kt) rt = 0.3 1; kt = 1200000.0 1
=> N; T tumor_microenvironment*k*T*(1-T/t) t = 300000.0 1; k = 0.028 1
Curator's comment:
(added: 25 Jul 2019, 14:48:11, updated: 25 Jul 2019, 15:36:31)
Publication figure 1 reproduced as per literature. Figure data is generated using COPASI 4.25 (build 197).