den Breems2015 - macrophage in cancer
- The re-polarisation of M2 and M1 macrophages and its role on cancer outcomes.
- den Breems NY, Eftimie R
- Journal of theoretical biology , 2/ 2016 , Volume 390 , pages: 23-39 , PubMed ID: 26551154
- Centre for Advanced Computational Solutions (C-fACS), Lincoln University, Lincoln 7476, New Zealand; Division of Mathematics, University of Dundee, Dundee DD1 4HN, United Kingdom; Division of Cancer Research, University of Dundee, Dundee DD1 9SY, United Kingdom. Electronic address: email@example.com.
- The anti-tumour and pro-tumour roles of Th1/Th2 immune cells and M1/M2 macrophages have been documented by numerous experimental studies. However, it is still unknown how these immune cells interact with each other to control tumour dynamics. Here, we use a mathematical model for the interactions between mouse melanoma cells, Th2/Th1 cells and M2/M1 macrophages, to investigate the unknown role of the re-polarisation between M1 and M2 macrophages on tumour growth. The results show that tumour growth is associated with a type-II immune response described by large numbers of Th2 and M2 cells. Moreover, we show that (i) the ratio k of the transition rates k12 (for the re-polarisation M1→M2) and k21 (for the re-polarisation M2→M1) is important in reducing tumour population, and (ii) the particular values of these transition rates control the delay in tumour growth and the final tumour size. We also perform a sensitivity analysis to investigate the effect of various model parameters on changes in the tumour cell population, and confirm that the ratio k alone and the ratio of M2 and M1 macrophage populations at earlier times (e.g., day 7) cannot always predict the final tumour size.
Submitter of this revision: Kausthubh Ramachandran
Modellers: Jinghao Men, Kausthubh Ramachandran
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Mathematical Modelling Ontology Ordinary differential equation model
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OmicsDI Impact Metrics
|denBreems2015.xml||SBML L2V5 representation of the macrophage transition in cancer model||109.12 KB||Preview | Download|
|den Breems2015.omex||COMBINE archive of the macrophage transition in cancer model||17.69 KB||Preview | Download|
|denBreems2015.cps||COPASI 4.29 (Build 228) representation of the macrophage transition in cancer model||137.15 KB||Preview | Download|
|denBreems2015.sedml||SED-ML representation of the macrophage transition in cancer model||5.05 KB||Preview | Download|
- Model originally submitted by : Jinghao Men
- Submitted: Jul 24, 2019 4:52:23 PM
- Last Modified: Mar 5, 2021 11:50:59 AM
- Submitted on: Mar 5, 2021 11:50:59 AM
- Submitted by: Kausthubh Ramachandran
- With comment: Updated model files - COPASI, SBML L2V5, SED-ML and COMBINE archive. Only SBML L3V1 and SED-ML files were previously available.
- Submitted on: Jul 24, 2019 4:52:23 PM
- Submitted by: Jinghao Men
- With comment: Automatically added model identifier BIOMD0000000759
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: Variable used inside SBML models
T-helper 1 cell
|=> M1; Ts, Th1, M2||tumor_microenvironment*(as*Ts+am1*Th1)*M1*(1-(M1+M2)/bm)||as = 1.0E-6 1/d; am1 = 5.0E-8 1/d; bm = 100000.0 1|
|M1 =>||tumor_microenvironment*dm1*M1||dm1 = 0.2 1/d|
|M2 => M1||tumor_microenvironment*k21*M2*M1||k21 = 4.0E-5 1/d|
|Ts => ; M1||tumor_microenvironment*dms*M1*Ts||dms = 2.0E-6 1/d|
|Ts => ; Th1||tumor_microenvironment*dts*Th1*Ts||dts = 5.3E-8 1/d|
|=> Tn; Ts||tumor_microenvironment*r*Tn*(1-(Tn+Ts)/bt)||r = 0.565 1/d; bt = 2.0E9 1|
|=> M2; Tn, Th2, M1||tumor_microenvironment*(an*Tn+am2*Th2)*M2*(1-(M2+M1)/bm)||an = 5.0E-8 1/d; bm = 100000.0 1; am2 = 5.0E-8 1/d|
|Tn => ; M1||tumor_microenvironment*dmn*M1*Tn||dmn = 2.0E-6 1/d|
|M1 => M2||tumor_microenvironment*k12*M1*M2||k12 = 5.0E-5 1/d|
|=> Th1; M1, Th2||tumor_microenvironment*rh1*M1*Th1*(1-(Th1+Th2)/bth)||rh1 = 9.0E-6 1/d; bth = 1.0E8 1|
(added: 24 Jul 2019, 16:51:53, updated: 24 Jul 2019, 16:51:53)