Norel1990 - MPF and Cyclin Oscillations

  public model
Model Identifier
BIOMD0000000728
Short description
A mathematical model of cell cycle progression is presented, which integrates recent biochemical information on the interaction of the maturation promotion factor (MPF) and cyclin. The model retrieves the dynamics observed in early embryos and explains how multiple cycles of MPF activity can be produced and how the internal clock that determines durations and number of cycles can be adjusted by modulating the rate of change in MPF or cyclin concentrations. Experiments are suggested for verifying the role of MPF activity in determining the length of the somatic cell cycle.
Format
SBML (L2V4)
Related Publication
  • A model for the adjustment of the mitotic clock by cyclin and MPF levels.
  • Norel R, Agur Z
  • Science (New York, N.Y.) , 3/ 1991 , Volume 251 , Issue 4997 , pages: 1076-1078 , PubMed ID: 1825521
  • Department of Applied Mathematics and Computer Science, Weizmann Institute of Science, Israel.
  • A mathematical model of cell cycle progression is presented, which integrates recent biochemical information on the interaction of the maturation promotion factor (MPF) and cyclin. The model retrieves the dynamics observed in early embryos and explains how multiple cycles of MPF activity can be produced and how the internal clock that determines durations and number of cycles can be adjusted by modulating the rate of change in MPF or cyclin concentrations. Experiments are suggested for verifying the role of MPF activity in determining the length of the somatic cell cycle.
Contributors
Submitter of the first revision: Ashley Xavier
Submitter of this revision: Ashley Xavier
Modellers: Ashley Xavier

Metadata information

is (2 statements)
BioModels Database MODEL1812120004
BioModels Database BIOMD0000000728

isDescribedBy (1 statement)
PubMed 1825521

hasTaxon (1 statement)
Taxonomy Homo sapiens

hasProperty (2 statements)
Mathematical Modelling Ontology Ordinary differential equation model
Gene Ontology mitotic cell cycle


Curation status
Curated


Tags

Connected external resources

SBGN view in Newt Editor

Name Description Size Actions

Model files

Norell1990.xml SBML file containing the model 28.71 KB Preview | Download

Additional files

Norell1990.cps copasi file to generate Figure 1A 45.88 KB Preview | Download

  • Model originally submitted by : Ashley Xavier
  • Submitted: Dec 12, 2018 11:53:09 AM
  • Last Modified: Dec 12, 2018 11:53:09 AM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Dec 12, 2018 11:53:09 AM
    • Submitted by: Ashley Xavier
    • With comment: Automatically added model identifier BIOMD0000000728
Legends
: Variable used inside SBML models


Species
Species Initial Concentration/Amount
M

MPF complex
0.4 mmol
C

Guanidine
0.8 mmol
Reactions
Reactions Rate Parameters
M => cell*g*M/(M+1) g = 10.0
C => ; M cell*M []
=> C cell*i i = 1.2
=> M; C cell*f*C*M^2 f = 1.0
Curator's comment:
(added: 12 Dec 2018, 11:52:40, updated: 12 Dec 2018, 11:52:40)
The parameter e was changed from 3.5 to 3.46616 to reproduce the publication figure 1 A