Nampala2013 - Liver enzyme elevation in HIV mono-infection

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Model Identifier
MODEL1812040002
Short description
the model depicts a unique endemic equilibrium with a transcritical bifurcation when the basic reproductive number is unity.
Format
SBML (L2V4)
Related Publication
  • Mathematical modeling of liver enzyme elevation in HIV mono-infection.
  • Nampala H, Luboobi LS, Mugisha JY, Obua C
  • Mathematical biosciences , 3/ 2013 , Volume 242 , Issue 1 , pages: 77-85 , PubMed ID: 23291466
  • Department of Mathematics, Makerere University, Kampala, Uganda. hnampala@yahoo.co.uk
  • HIV-infected individuals are increasingly becoming susceptible to liver disease and, hence, liver-related mortality is on a rise. The presence of CD4+ in the liver and the presence of C-X-C chemokine receptor type 4 (CXCR4) on human hepatocytes provide a conducive environment for HIV invasion. In this study, a mathematical model is used to analyse the dynamics of HIV in the liver with the aim of investigating the existence of liver enzyme elevation in HIV mono-infected individuals. In the presence of HIV-specific cytotoxic T-lymphocytes, the model depicts a unique endemic equilibrium with a transcritical bifurcation when the basic reproductive number is unity. Results of the study show that the level of liver enzyme alanine aminotransferase (ALT) increases with increase in the rate of hepatocytes production. Numerical simulations reveal significant elevation of alanine aminotransferase with increase in viral load. The findings presuppose that while liver damage in HIV infection has mostly been associated with HIV/HBV coinfection and use of antiretroviral therapy (ART), it is possible to have liver damage solely with HIV infection.
Contributors
Submitter of the first revision: Sarubini Kananathan
Submitter of this revision: Krishna Kumar Tiwari
Modellers: Sarubini Kananathan, Krishna Kumar Tiwari

Metadata information

hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model

Curation status
Non-curated
Modelling approach(es)
ordinary differential equation model
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Model files
Model.xml SBML file for the model 17.06 KB Preview | Download

Additional files
VS1 Pub.cps Copasi file for the model 44.88 KB Preview | Download

  • Model originally submitted by : Sarubini Kananathan
  • Submitted: Jul 9, 2020 1:45:55 PM
  • Last Modified: Jul 9, 2020 1:45:55 PM
Revisions
  • Version: 4 public model Download this version
    • Submitted on: Jul 9, 2020 1:45:55 PM
    • Submitted by: Krishna Kumar Tiwari
    • With comment: Edited model metadata online.