Pokhilko1998 - Intrinsic Activation Kinetics (Dimensional Model)

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Short description
Mathematical model of intrinsic pathway activation consisting of XIIa, kallikrein and HMWKa.
Related Publication
  • Contact Activation of Blood Coagulation: Trigger Properties and Hysteresis Hypothesis: Kinetic Recognition of Foreign Surfaces upon Contact Activation of Blood Coagulation: A Hypothesis
  • Pokhilko, A.V., Ataullakhanov, F.I.
  • Journal of Theoretical Biology , 3/ 1998 , Volume 191 , Issue 2 , pages: 213-219 , DOI: 10.1006/jtbi.1997.0584
  • National Research Center for Hematology, Novozykovskij pr. 4a, 125167, Moscow, Russia
  • A mathematical model of contact activation of blood coagulation was developed and analysed. The model variables are concentrations of factor XIIa, kallikrein and activated high-molecular-weight kininogen. Concentrations of active factors were shown to depend on the activating signal value in a hysteretic manner. Within a range of relatively small signals, two (activated and non-activated) stable states coexist (bistability). Signals of the natural environment (surfaces of endothelial and blood cells) seem to be in the range of bistability; therefore, contact activation that persists for a short time can induce a transition of the system to the activated state, and, correspondingly, the formation of a clot. The system cannot return to the initial state, which is characterized by low activation levels, until the activating signals decrease significantly below those present in the circulation.
Submitter of the first revision: Matthew Roberts
Submitter of this revision: Matthew Roberts
Modellers: Matthew Roberts

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isPartOf (1 statement)
Gene Ontology blood coagulation

isDescribedBy (1 statement)

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Model files

Pokhilko1998_dimensional.xml SBML L2V4 representation of Pokhilko1998 - Intrinsic Activation Kinetics (Dimensional Model) 9.96 KB Preview | Download

Additional files

Pokhilko1998_dimensional.cps Model COPASI file for dimensional (set 1) model. 36.48 KB Preview | Download
Pokhilko1998_nondimensional.cps Model COPASI file for nondimensional (set 4) model. Parameter scan setup to reproduce figure 2 34.52 KB Preview | Download

  • Model originally submitted by : Matthew Roberts
  • Submitted: Aug 21, 2018 4:04:06 PM
  • Last Modified: Aug 21, 2018 4:04:06 PM
  • Version: 2 public model Download this version
    • Submitted on: Aug 21, 2018 4:04:06 PM
    • Submitted by: Matthew Roberts
    • With comment: Edited model metadata online.