Uhlén2017 - TCGA-2J-AAB1-01A - Pancreatic Adenocarcinoma (male, 66 years)

  public model
Model Identifier
MODEL1707110502
Short description

This is a whole genome metabolism model of a male patient diagnosed at the age of 66 years with Pancreatic Adenocarcinoma affecting the patient's pancreas.

This model was automatically generated by tINIT (Agren, R., et al. (2014). Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol; 10(3), 721.) using information coming from the sample TCGA-2J-AAB1-01A from GDC Portal (Initial release 1.0, accessed via GDC API) and, where relevant, augmented with metabolic pathway information extracted from Human Metabolic Atlas.

This model has been produced by Human Pathology Atlas project ( Uhlen, M., et al.; A pathology atlas of the human cancer transcriptome. Science.) and is currently hosted on BioModels Database and identified by MODEL1707110502.

Other models with the same disease include MODEL1707110503 MODEL1707110504 MODEL1707110505 MODEL1707110506 MODEL1707110507 MODEL1707110508 MODEL1707110509 MODEL1707110510 MODEL1707110511 MODEL1707110512 MODEL1707110513 MODEL1707110514 MODEL1707110515 MODEL1707110516 MODEL1707110518 MODEL1707110519 MODEL1707110520 MODEL1707110521 MODEL1707110667 MODEL1707110668 MODEL1707110669 MODEL1707110670 MODEL1707110671 MODEL1707110672 MODEL1707110673 MODEL1707110674 MODEL1707110675 MODEL1707110676 MODEL1707110677 MODEL1707110678 MODEL1707110679 MODEL1707110680 MODEL1707110681 MODEL1707110682 MODEL1707110683 MODEL1707110687 MODEL1707115076 MODEL1707115077 MODEL1707115078 MODEL1707115079 MODEL1707115080 MODEL1707115081 MODEL1707115082 MODEL1707115118 MODEL1707115119 MODEL1707115120 MODEL1707115121 MODEL1707115122 MODEL1707115123 MODEL1707115124 MODEL1707115125 MODEL1707115126 MODEL1707115127 MODEL1707115128 MODEL1707115129 MODEL1707115130 MODEL1707115131 MODEL1707115132 MODEL1707115468 MODEL1707115469 MODEL1707115474 MODEL1707115603 MODEL1707115604 MODEL1707115605 MODEL1707115606 MODEL1707115607 MODEL1707115608 MODEL1707115609 MODEL1707115610 MODEL1707115611 MODEL1707115612 MODEL1707115613 MODEL1707115614 MODEL1707115615 MODEL1707115616 MODEL1707115617 MODEL1707115618 MODEL1707115619 MODEL1707115620 MODEL1707115621 MODEL1707115622 MODEL1707115623 MODEL1707115624 MODEL1707115625 MODEL1707115626 MODEL1707115627 MODEL1707115628 MODEL1707115629 MODEL1707115630 MODEL1707115631 MODEL1707115632 MODEL1707115633 MODEL1707115634 MODEL1707115635 MODEL1707115636 MODEL1707115643 MODEL1707115644 MODEL1707115645 MODEL1707115646 MODEL1707115647 MODEL1707115648 MODEL1707115649 MODEL1707115650 MODEL1707115651 MODEL1707115652 MODEL1707115653 MODEL1707115654 MODEL1707115655 MODEL1707115656 MODEL1707115657 MODEL1707115658 MODEL1707115659 MODEL1707115660 MODEL1707115661 MODEL1707115662 MODEL1707115663 MODEL1707115664 MODEL1707115665 MODEL1707115666 MODEL1707115667 MODEL1707115668 MODEL1707115669 MODEL1707115670 MODEL1707115671 MODEL1707115672 MODEL1707115673 MODEL1707115674 MODEL1707115675 MODEL1707115676 MODEL1707115677 MODEL1707115939 MODEL1707115953 MODEL1707115954 MODEL1707115955 MODEL1707115994 MODEL1707116096 MODEL1707116155 MODEL1707116166 MODEL1707116167 MODEL1707116205 MODEL1707116206 MODEL1707116229 MODEL1707116241 MODEL1707116242 MODEL1707116243 MODEL1707116314 MODEL1707116315 MODEL1707116316 MODEL1707116317 MODEL1707116318 MODEL1707116319 MODEL1707116528 MODEL1707116529 MODEL1707116530 MODEL1707116602 MODEL1707116603 MODEL1707116632 MODEL1707116638 MODEL1707116675 MODEL1707116676 .

To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Format
SBML (L2V3)
Related Publication
  • A pathology atlas of the human cancer transcriptome.
  • Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F
  • Science (New York, N.Y.) , 8/ 2017 , Volume 357 , Issue 6352 , PubMed ID: 28818916
  • School of Biotechnology, AlbaNova University Center, KTH-Royal Institute of Technology, Stockholm, Sweden.
  • Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.
Contributors
Adil Mardinoglu

Metadata information


Curation status
Non-curated

Name Description Size Actions

Model files

MODEL1707110502.xml Patient derived genome scale metabolic model for Pancreatic Adenocarcinoma 10.25 MB Preview | Download

Additional files

Pancreatic Adenocarcinoma.zip All 'Pancreatic Adenocarcinoma' models 42.94 MB Preview | Download

  • Model originally submitted by : Adil Mardinoglu
  • Submitted: Aug 17, 2017 5:07:37 PM
  • Last Modified: Jan 7, 2020 5:51:19 PM
Revisions
  • Version: 3 public model Download this version
    • Submitted on: Jan 7, 2020 5:51:19 PM
    • Submitted by: Adil Mardinoglu
    • With comment: Import of 'Uhlén2017 - TCGA-2J-AAB1-01A - Pancreatic Adenocarcinoma (male, 66 years)'.
  • Version: 2 public model Download this version
    • Submitted on: Aug 17, 2017 5:07:24 PM
    • Submitted by: Adil Mardinoglu
    • With comment: Current version of Uhlén2017 - TCGA-2J-AAB1-01A - Pancreatic Adenocarcinoma (male, 66 years)
  • Version: 1 public model Download this version
    • Submitted on: Aug 17, 2017 5:07:37 PM
    • Submitted by: Adil Mardinoglu
    • With comment: Original import of MODEL1707110502.xml.origin
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