FelixGarza2017 - Blue Light Treatment of Psoriasis (simplified)
This model is described in the article:
Abstract:
Clinical investigations prove that blue light irradiation reduces the severity of psoriasis vulgaris. Nevertheless, the mechanisms involved in the management of this condition remain poorly defined. Despite the encouraging results of the clinical studies, no clear guidelines are specified in the literature for the irradiation scheme regime of blue light-based therapy for psoriasis. We investigated the underlying mechanism of blue light irradiation of psoriatic skin, and tested the hypothesis that regulation of proliferation is a key process. We implemented a mechanistic model of cellular epidermal dynamics to analyze whether a temporary decrease of keratinocytes hyper-proliferation can explain the outcome of phototherapy with blue light. Our results suggest that the main effect of blue light on keratinocytes impacts the proliferative cells. They show that the decrease in the keratinocytes proliferative capacity is sufficient to induce a transient decrease in the severity of psoriasis. To study the impact of the therapeutic regime on the efficacy of psoriasis treatment, we performed simulations for different combinations of the treatment parameters, i.e., length of treatment, fluence (also referred to as dose), and intensity. These simulations indicate that high efficacy is achieved by regimes with long duration and high fluence levels, regardless of the chosen intensity. Our modeling approach constitutes a framework for testing diverse hypotheses on the underlying mechanism of blue light-based phototherapy, and for designing effective strategies for the treatment of psoriasis.
This model is hosted on BioModels Database and identified by: BIOMD0000000695.
To cite BioModels Database, please use: Chelliah V et al. BioModels: ten-year anniversary. Nucl. Acids Res. 2015, 43(Database issue):D542-8.
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
-
A Dynamic Model for Prediction of Psoriasis Management by Blue Light Irradiation.
- Félix Garza ZC, Liebmann J, Born M, Hilbers PA, van Riel NA
- Frontiers in physiology , 0/ 2017 , Volume 8 , pages: 28 , PubMed ID: 28184200
- Department of Biomedical Engineering, Eindhoven University of Technology Eindhoven, Netherlands.
- Clinical investigations prove that blue light irradiation reduces the severity of psoriasis vulgaris. Nevertheless, the mechanisms involved in the management of this condition remain poorly defined. Despite the encouraging results of the clinical studies, no clear guidelines are specified in the literature for the irradiation scheme regime of blue light-based therapy for psoriasis. We investigated the underlying mechanism of blue light irradiation of psoriatic skin, and tested the hypothesis that regulation of proliferation is a key process. We implemented a mechanistic model of cellular epidermal dynamics to analyze whether a temporary decrease of keratinocytes hyper-proliferation can explain the outcome of phototherapy with blue light. Our results suggest that the main effect of blue light on keratinocytes impacts the proliferative cells. They show that the decrease in the keratinocytes proliferative capacity is sufficient to induce a transient decrease in the severity of psoriasis. To study the impact of the therapeutic regime on the efficacy of psoriasis treatment, we performed simulations for different combinations of the treatment parameters, i.e., length of treatment, fluence (also referred to as dose), and intensity. These simulations indicate that high efficacy is achieved by regimes with long duration and high fluence levels, regardless of the chosen intensity. Our modeling approach constitutes a framework for testing diverse hypotheses on the underlying mechanism of blue light-based phototherapy, and for designing effective strategies for the treatment of psoriasis.
Submitter of this revision: administrator
Modellers: administrator, Zandra Felix Garza
Metadata information
isDescribedBy (2 statements)
hasPart (3 statements)
Gene Ontology response to blue light
Brenda Tissue Ontology keratinocyte
occursIn (1 statement)
Connected external resources
SBGN view in Newt Editor
| Name | Description | Size | Actions |
|---|---|---|---|
Model files |
|||
| BIOMD0000000695_url.xml | SBML L2V4 representation of FelixGarza2017 - Blue Light Treatment of Psoriasis (simplified) | 217.35 KB | Preview | Download |
Additional files |
|||
| BIOMD0000000695-biopax2.owl | Auto-generated BioPAX (Level 2) | 43.99 KB | Preview | Download |
| BIOMD0000000695-biopax3.owl | Auto-generated BioPAX (Level 3) | 76.25 KB | Preview | Download |
| BIOMD0000000695.m | Auto-generated Octave file | 21.66 KB | Preview | Download |
| BIOMD0000000695.pdf | Auto-generated PDF file | 261.14 KB | Preview | Download |
| BIOMD0000000695.png | Auto-generated Reaction graph (PNG) | 393.54 KB | Preview | Download |
| BIOMD0000000695.sci | Auto-generated Scilab file | 67.00 Bytes | Preview | Download |
| BIOMD0000000695.svg | Auto-generated Reaction graph (SVG) | 63.49 KB | Preview | Download |
| BIOMD0000000695.vcml | Auto-generated VCML file | 897.00 Bytes | Preview | Download |
| BIOMD0000000695.xpp | Auto-generated XPP file | 18.08 KB | Preview | Download |
| BIOMD0000000695_urn.xml | Auto-generated SBML file with URNs | 217.23 KB | Preview | Download |
| MODEL1701090001.cps | Curated and annotated COPASI file. | 300.16 KB | Preview | Download |
| MODEL1701090001.sedml | SED-ML file for figure 5A and 5B of the publication. | 8.80 KB | Preview | Download |
- Model originally submitted by : Zandra Felix Garza
- Submitted: Jan 9, 2017 11:08:18 AM
- Last Modified: Apr 24, 2018 10:15:32 AM
Revisions
-
Version: 3
- Submitted on: Apr 24, 2018 10:15:32 AM
- Submitted by: administrator
- With comment: Notes updated using online editor.
-
Version: 2
- Submitted on: Jan 30, 2017 10:16:17 AM
- Submitted by: Zandra Felix Garza
- With comment: Current version of FelixGarza2017 - BlueLight Treatment of Psoriasis (simplified)
-
Version: 1
- Submitted on: Jan 9, 2017 11:08:18 AM
- Submitted by: Zandra Felix Garza
- With comment: Original import of FelixGarza2017_BlueLightTreatmentofPsoriasis_simplified
(*) You might be seeing discontinuous
revisions as only public revisions are displayed here. Any private revisions
of this model will only be shown to the submitter and their collaborators.
: Variable used inside SBML models
| Species | Initial Concentration/Amount |
|---|---|
| xFinal 7 keratinocyte ; stem cell |
6459.0 mmol |
| xFinal 10 keratinocyte |
79788.0 mmol |
| xFinal 12 keratinocyte ; corneocyte |
77633.0 mmol |
| xFinal 2 keratinocyte |
77.0 mmol |
| xFinal 6 keratinocyte ; corneocyte |
185.0 mmol |
| xFinal 8 keratinocyte |
32098.0 mmol |
| xFinal 1 keratinocyte ; stem cell |
362.0 mmol |
| xFinal 3 keratinocyte ; cell cycle arrest |
61.0 mmol |
| Reactions | Rate | Parameters |
|---|---|---|
| xFinal_1 + xFinal_2 + xFinal_7 + xFinal_8 => xFinal_2 + xFinal_7 + xFinal_8 | gamma1h*aProl*exp(bProl*doseBL)*xFinal_1*omega*xFinal_7/(1+(omega-1)*((xFinal_2+xFinal_8)/Ptah)^n)/lambda/Pscmax/compartmentOne | Pscmax = 4500.0; n = 3.0; lambda = 3.5; bProl = -0.003404; doseBL = 52.11; Ptah = 11184.7844353585; aProl = 1.0; gamma1h = 0.0033; omega = 100.0 |
| xFinal_9 => xFinal_10 | Psoriatic*k3*rhoTr*xFinal_9/compartmentOne | rhoTr = 5.0; k3 = 0.216 |
| xFinal_10 => xFinal_12 | Psoriatic*k4*rhoTr*xFinal_10/compartmentOne | rhoTr = 5.0; k4 = 0.0556 |
| xFinal_1 + xFinal_2 + xFinal_8 => xFinal_1 + xFinal_2 + xFinal_8 | aProl*gamma1h*exp(bProl*doseBL)*xFinal_1*omega/(1+(omega-1)*((xFinal_2+xFinal_8)/Ptah)^n)/compartmentOne | n = 3.0; bProl = -0.003404; doseBL = 52.11; Ptah = 11184.7844353585; aProl = 1.0; gamma1h = 0.0033; omega = 100.0 |
| xFinal_6 + xFinal_7 => xFinal_6 | aProl*gamma1h*rhoSC*exp(bProl*doseBL)*xFinal_7*xFinal_6/(lambda*Pscmax)/compartmentOne | Pscmax = 4500.0; lambda = 3.5; bProl = -0.003404; doseBL = 52.11; aProl = 1.0; rhoSC = 4.0; gamma1h = 0.0033 |
| xFinal_3 => xFinal_4 | compartmentOne*k3*xFinal_3/compartmentOne | k3 = 0.216 |
| xFinal_5 => xFinal_6 | compartmentOne*k5*xFinal_5/compartmentOne | k5 = 0.111 |
(added: 24 Apr 2018, 11:51:49, updated: 24 Apr 2018, 11:51:49)