Kogan2001_aPTT_coagulation

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This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V4)
Related Publication
  • Analysis of the activated partial thromboplastin time test using mathematical modeling.
  • Kogan AE, Kardakov DV, Khanin MA
  • Thrombosis research , 2/ 2001 , Volume 101 , pages: 299-310
  • Biological Faculty, Department of Biochemistry, Room 129, Moscow State University, 119899, Moscow, Russia. al.kogan@mtu-net.ru
  • Activated partial thromboplastin time (APTT) is a laboratory test for the diagnosis of blood coagulation disorders. The test consists of two stages: The first one is the preincubation of a plasma sample with negatively charged materials (kaolin, ellagic acid etc.) to activate factors XII and XI; the second stage begins after the addition of calcium ions that triggers a chain of calcium-dependent enzymatic reactions resulting in fibrinogen clotting. Mathematical modeling was used for the analysis of the APTT test. The process of coagulation was described by a set of coupled differential equations that were solved by the numerical method. It was found that as little as 2.3 x 10(-9) microM of factor XIIa (1/10000 of its plasma concentration) is enough to cause the complete activation of factor XII and prekallikrein (PK) during the first 20 s of the preincubation phase. By the end of this phase, kallikrein (K) is completely inhibited, residual activity of factor XIIa is 54%, and factor XI is activated by 26%. Once a clot is formed, factor II is activated by 4%, factor X by 5%, factor IX by 90%, and factor XI by 39%. Calculated clotting time using protein concentrations found in the blood of healthy people was 40.5 s. The most pronounced prolongation of APTT is caused by a decrease in factor X concentration.
Contributors
Michael Schubert

Metadata information

is
BioModels Database MODEL1109160001
isDescribedBy
PubMed 11248291
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
Curation status
Non-curated
Name Description Size Actions

Model files

MODEL1109160001_url.xml SBML L2V4 representation of Kogan2001_aPTT_coagulation 75.42 KB Preview | Download

Additional files

MODEL1109160001.svg Auto-generated Reaction graph (SVG) 69.54 KB Preview | Download
MODEL1109160001.vcml Auto-generated VCML file 574.00 bytes Preview | Download
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MODEL1109160001.sci Auto-generated Scilab file 13.30 KB Preview | Download
MODEL1109160001.pdf Auto-generated PDF file 218.45 KB Preview | Download
MODEL1109160001.m Auto-generated Octave file 15.38 KB Preview | Download
MODEL1109160001_urn.xml Auto-generated SBML file with URNs 74.88 KB Preview | Download
MODEL1109160001-biopax2.owl Auto-generated BioPAX (Level 2) 40.93 KB Preview | Download
MODEL1109160001-biopax3.owl Auto-generated BioPAX (Level 3) 75.00 KB Preview | Download

  • Model originally submitted by : Michael Schubert
  • Submitted: Sep 16, 2011 11:07:00 AM
  • Last Modified: Sep 16, 2011 11:09:38 AM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Sep 16, 2011 11:09:38 AM
    • Submitted by: Michael Schubert
    • With comment: Current version of Kogan2001_aPTT_coagulation
  • Version: 1 public model Download this version
    • Submitted on: Sep 16, 2011 11:07:00 AM
    • Submitted by: Michael Schubert
    • With comment: Original import of Kogan2001_aPTT_coagulation