public model
Short description

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not..

To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Related Publication
  • Analysis of the activated partial thromboplastin time test using mathematical modeling.
  • Kogan AE, Kardakov DV, Khanin MA
  • Thrombosis research , 2/ 2001 , Volume 101 , pages: 299-310
  • Biological Faculty, Department of Biochemistry, Room 129, Moscow State University, 119899, Moscow, Russia. al.kogan@mtu-net.ru
  • Activated partial thromboplastin time (APTT) is a laboratory test for the diagnosis of blood coagulation disorders. The test consists of two stages: The first one is the preincubation of a plasma sample with negatively charged materials (kaolin, ellagic acid etc.) to activate factors XII and XI; the second stage begins after the addition of calcium ions that triggers a chain of calcium-dependent enzymatic reactions resulting in fibrinogen clotting. Mathematical modeling was used for the analysis of the APTT test. The process of coagulation was described by a set of coupled differential equations that were solved by the numerical method. It was found that as little as 2.3 x 10(-9) microM of factor XIIa (1/10000 of its plasma concentration) is enough to cause the complete activation of factor XII and prekallikrein (PK) during the first 20 s of the preincubation phase. By the end of this phase, kallikrein (K) is completely inhibited, residual activity of factor XIIa is 54%, and factor XI is activated by 26%. Once a clot is formed, factor II is activated by 4%, factor X by 5%, factor IX by 90%, and factor XI by 39%. Calculated clotting time using protein concentrations found in the blood of healthy people was 40.5 s. The most pronounced prolongation of APTT is caused by a decrease in factor X concentration.
Michael Schubert

Metadata information

BioModels Database MODEL1109160001
PubMed 11248291
Mathematical Modelling Ontology Ordinary differential equation model
Curation status
Name Description Size Actions

Model files

MODEL1109160001_url.xml SBML L2V4 representation of Kogan2001_aPTT_coagulation 75.42 KB Preview | Download

Additional files

MODEL1109160001.svg Auto-generated Reaction graph (SVG) 69.54 KB Preview | Download
MODEL1109160001.vcml Auto-generated VCML file 574.00 bytes Preview | Download
MODEL1109160001.png Auto-generated Reaction graph (PNG) 295.61 KB Preview | Download
MODEL1109160001.xpp Auto-generated XPP file 12.60 KB Preview | Download
MODEL1109160001.sci Auto-generated Scilab file 13.30 KB Preview | Download
MODEL1109160001.pdf Auto-generated PDF file 218.45 KB Preview | Download
MODEL1109160001.m Auto-generated Octave file 15.38 KB Preview | Download
MODEL1109160001_urn.xml Auto-generated SBML file with URNs 74.88 KB Preview | Download
MODEL1109160001-biopax2.owl Auto-generated BioPAX (Level 2) 40.93 KB Preview | Download
MODEL1109160001-biopax3.owl Auto-generated BioPAX (Level 3) 75.00 KB Preview | Download

  • Model originally submitted by : Michael Schubert
  • Submitted: Sep 16, 2011 11:07:00 AM
  • Last Modified: Sep 16, 2011 11:09:38 AM
  • Version: 2 public model Download this version
    • Submitted on: Sep 16, 2011 11:09:38 AM
    • Submitted by: Michael Schubert
    • With comment: Current version of Kogan2001_aPTT_coagulation
  • Version: 1 public model Download this version
    • Submitted on: Sep 16, 2011 11:07:00 AM
    • Submitted by: Michael Schubert
    • With comment: Original import of Kogan2001_aPTT_coagulation