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This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Related Publication
  • Mathematical model of serine protease inhibition in the tissue factor pathway to thrombin.
  • Leipold RJ, Bozarth TA, Racanelli AL, Dicker IB
  • The Journal of biological chemistry , 10/ 1995 , Volume 270 , pages: 25383-25387 , PubMed ID: 7592704
  • DuPont Merck Pharmaceutical Company, Wilmington, Delaware 19880-0400, USA.
  • A mathematical model has been developed to simulate the generation of thrombin by the tissue factor pathway. The model gives reasonable predictions of published experimental results without the adjustment of any parameter values. The model also accounts explicitly for the effects of serine protease inhibitors on thrombin generation. Simulations to define the optimum affinity profile of an inhibitor in this system indicate that for an inhibitor simultaneously potent against VIIa, IXa, and Xa, inhibition of thrombin generation decreases dramatically as the affinity for thrombin increases. Additional simulations show that the reason for this behavior is the sequestration of the inhibitor by small amounts of thrombin generated early in the reaction. This model is also useful for predicting the potency of compounds that inhibit thrombosis in rats. We believe that this is the first mathematical model of blood coagulation that considers the effects of exogenous inhibitors. Such a model, or extensions thereof, should be useful for evaluating targets for therapeutic intervention in the processes of blood coagulation.
Submitter of the first revision: Michael Schubert
Submitter of this revision: Michael Schubert
Modellers: Michael Schubert

Metadata information

is (1 statement)
BioModels Database MODEL1109150002

isDescribedBy (1 statement)
PubMed 7592704

hasTaxon (1 statement)
Taxonomy Homo sapiens

isVersionOf (1 statement)
Gene Ontology blood coagulation

hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model

Curation status


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Model files

MODEL1109150002_url.xml SBML L2V4 representation of Leipold1995_ThrombinFormation+inhibitors 85.37 KB Preview | Download

Additional files

MODEL1109150002-biopax2.owl Auto-generated BioPAX (Level 2) 66.84 KB Preview | Download
MODEL1109150002-biopax3.owl Auto-generated BioPAX (Level 3) 129.47 KB Preview | Download
MODEL1109150002.m Auto-generated Octave file 23.06 KB Preview | Download
MODEL1109150002.pdf Auto-generated PDF file 248.63 KB Preview | Download
MODEL1109150002.png Auto-generated Reaction graph (PNG) 648.84 KB Preview | Download
MODEL1109150002.sci Auto-generated Scilab file 21.35 KB Preview | Download
MODEL1109150002.svg Auto-generated Reaction graph (SVG) 115.70 KB Preview | Download
MODEL1109150002.vcml Auto-generated VCML file 574.00 Bytes Preview | Download
MODEL1109150002.xpp Auto-generated XPP file 19.14 KB Preview | Download
MODEL1109150002_urn.xml Auto-generated SBML file with URNs 95.38 KB Preview | Download

  • Model originally submitted by : Michael Schubert
  • Submitted: Sep 15, 2011 2:26:29 PM
  • Last Modified: Sep 15, 2011 2:32:24 PM
  • Version: 2 public model Download this version
    • Submitted on: Sep 15, 2011 2:32:24 PM
    • Submitted by: Michael Schubert
    • With comment: Current version of Leipold1995_ThrombinFormation+inhibitors
  • Version: 1 public model Download this version
    • Submitted on: Sep 15, 2011 2:26:29 PM
    • Submitted by: Michael Schubert
    • With comment: Original import of Leipold1995_ThrombinFormation+inhibitors

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