public model
Model Identifier
Short description

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not..

To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Related Publication
  • Surface-mediated control of blood coagulation: the role of binding site densities and platelet deposition.
  • Kuharsky AL, Fogelson AL
  • Biophysical Journal , 3/ 2001 , Volume 80 , pages: 1050-1074 , PubMed ID: 11222273
  • Generation5, Toronto, Ontario, Canada.
  • A mathematical model of the extrinsic or tissue factor (TF) pathway of blood coagulation is formulated and results from a computational study of its behavior are presented. The model takes into account plasma-phase and surface-bound enzymes and zymogens, coagulation inhibitors, and activated and unactivated platelets. It includes both plasma-phase and membrane-phase reactions, and accounts for chemical and cellular transport by flow and diffusion, albeit in a simplified manner by assuming the existence of a thin, well-mixed fluid layer, near the surface, whose thickness depends on flow. There are three main conclusions from these studies. (i) The model system responds in a threshold manner to changes in the availability of particular surface binding sites; an increase in TF binding sites, as would occur with vascular injury, changes the system's production of thrombin dramatically. (ii) The model suggests that platelets adhering to and covering the subendothelium, rather than chemical inhibitors, may play the dominant role in blocking the activity of the TF:VIIa enzyme complex. This, in turn, suggests that a role of the IXa-tenase pathway for activating factor X to Xa is to continue factor Xa production after platelets have covered the TF:VIIa complexes on the subendothelium. (iii) The model gives a kinetic explanation of the reduced thrombin production in hemophilias A and B.
Submitter of the first revision: Michael Schubert
Submitter of this revision: Michael Schubert
Modellers: Michael Schubert

Metadata information

is (1 statement)
BioModels Database MODEL1109150000

isDescribedBy (1 statement)
PubMed 11222273

hasTaxon (1 statement)
Taxonomy Homo sapiens

isVersionOf (1 statement)
Gene Ontology blood coagulation

hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model

Curation status


Connected external resources

SBGN view in Newt Editor

Name Description Size Actions

Model files

MODEL1109150000_url.xml SBML L2V4 representation of Kuharsky2001_BloodCoagulation 191.29 KB Preview | Download

Additional files

MODEL1109150000-biopax2.owl Auto-generated BioPAX (Level 2) 105.02 KB Preview | Download
MODEL1109150000-biopax3.owl Auto-generated BioPAX (Level 3) 197.72 KB Preview | Download
MODEL1109150000.m Auto-generated Octave file 42.36 KB Preview | Download
MODEL1109150000.pdf Auto-generated PDF file 367.62 KB Preview | Download
MODEL1109150000.png Auto-generated Reaction graph (PNG) 1.01 MB Preview | Download
MODEL1109150000.sci Auto-generated Scilab file 31.87 KB Preview | Download
MODEL1109150000.svg Auto-generated Reaction graph (SVG) 206.24 KB Preview | Download
MODEL1109150000.vcml Auto-generated VCML file 576.00 Bytes Preview | Download
MODEL1109150000.xpp Auto-generated XPP file 34.64 KB Preview | Download
MODEL1109150000_urn.xml Auto-generated SBML file with URNs 215.35 KB Preview | Download

  • Model originally submitted by : Michael Schubert
  • Submitted: Sep 15, 2011 2:19:47 PM
  • Last Modified: Sep 15, 2011 2:31:35 PM
  • Version: 2 public model Download this version
    • Submitted on: Sep 15, 2011 2:31:35 PM
    • Submitted by: Michael Schubert
    • With comment: Current version of Kuharsky2001_BloodCoagulation
  • Version: 1 public model Download this version
    • Submitted on: Sep 15, 2011 2:19:47 PM
    • Submitted by: Michael Schubert
    • With comment: Original import of Kuharsky2001_BloodCoagulation

(*) You might be seeing discontinuous revisions as only public revisions are displayed here. Any private revisions unpublished model revision of this model will only be shown to the submitter and their collaborators.