Wodarz2007 - Cytomegalovirus infection model with cytotoxic T lymphocyte and natural killer cell response
This a model from the article:
Dynamics of killer T cell inflation in viral infections.
Wodarz D, Sierro S, Klenerman P. J R Soc Interface
2007 Jun 22;4(14):533-43 17251133
,
Abstract:
Upon acute viral infection, a typical cytotoxic T lymphocyte (CTL) response is
characterized by a phase of expansion and contraction after which it settles at
a relatively stable memory level. Recently, experimental data from mice infected
with murine cytomegalovirus (MCMV) showed different and unusual dynamics. After
acute infection had resolved, some antigen specific CTL started to expand over
time despite the fact that no replicative virus was detectable. This phenomenon
has been termed as "CTL memory inflation". In order to examine the dynamics of
this system further, we developed a mathematical model analysing the impact of
innate and adaptive immune responses. According to this model, a potentially
important contributor to CTL inflation is competition between the specific CTL
response and an innate natural killer (NK) cell response. Inflation occurs most
readily if the NK cell response is more efficient than the CTL at reducing virus
load during acute infection, but thereafter maintains a chronic virus load which
is sufficient to induce CTL proliferation. The model further suggests that
weaker NK cell mediated protection can correlate with more pronounced CTL
inflation dynamics over time. We present experimental data from mice infected
with MCMV which are consistent with the theoretical predictions. This model
provides valuable information and may help to explain the inflation of CMV
specific CD8+T cells seen in humans as they age.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Wodarz D, Sierro S, Klenerman P. (2007) - version=1.0
The original CellML model was created by:
Catherine Lloyd
c.lloyd@auckland.ac.nz
The University of Auckland
This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
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In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not..
To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
-
Dynamics of killer T cell inflation in viral infections.
- Wodarz D, Sierro S, Klenerman P
- Journal of the Royal Society, Interface , 6/ 2007 , Volume 4 , Issue 14 , pages: 533-543 , PubMed ID: 17251133
- Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA. dwodarz@uci.edu
- Upon acute viral infection, a typical cytotoxic T lymphocyte (CTL) response is characterized by a phase of expansion and contraction after which it settles at a relatively stable memory level. Recently, experimental data from mice infected with murine cytomegalovirus (MCMV) showed different and unusual dynamics. After acute infection had resolved, some antigen specific CTL started to expand over time despite the fact that no replicative virus was detectable. This phenomenon has been termed as "CTL memory inflation". In order to examine the dynamics of this system further, we developed a mathematical model analysing the impact of innate and adaptive immune responses. According to this model, a potentially important contributor to CTL inflation is competition between the specific CTL response and an innate natural killer (NK) cell response. Inflation occurs most readily if the NK cell response is more efficient than the CTL at reducing virus load during acute infection, but thereafter maintains a chronic virus load which is sufficient to induce CTL proliferation. The model further suggests that weaker NK cell mediated protection can correlate with more pronounced CTL inflation dynamics over time. We present experimental data from mice infected with MCMV which are consistent with the theoretical predictions. This model provides valuable information and may help to explain the inflation of CMV specific CD8+T cells seen in humans as they age.
Submitter of this revision: administrator
Modellers: administrator, Camille Laibe
Metadata information
isDescribedBy (2 statements)
hasTaxon (1 statement)
isVersionOf (1 statement)
hasPart (3 statements)
Brenda Tissue Ontology natural killer cell
Experimental Factor Ontology cytomegalovirus infection
isDerivedFrom (1 statement)
Connected external resources
SBGN view in Newt Editor
| Name | Description | Size | Actions |
|---|---|---|---|
Model files |
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| BIOMD0000000688_url.xml | SBML L2V4 representation of Wodarz2007 - Cytomegalovirus infection model with cytotoxic T lymphocyte and natural killer cell response | 109.72 KB | Preview | Download |
Additional files |
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| BIOMD0000000688-biopax2.owl | Auto-generated BioPAX (Level 2) | 36.24 KB | Preview | Download |
| BIOMD0000000688-biopax3.owl | Auto-generated BioPAX (Level 3) | 57.79 KB | Preview | Download |
| BIOMD0000000688.m | Auto-generated Octave file | 12.08 KB | Preview | Download |
| BIOMD0000000688.pdf | Auto-generated PDF file | 213.99 KB | Preview | Download |
| BIOMD0000000688.png | Auto-generated Reaction graph (PNG) | 119.67 KB | Preview | Download |
| BIOMD0000000688.sci | Auto-generated Scilab file | 4.81 KB | Preview | Download |
| BIOMD0000000688.svg | Auto-generated Reaction graph (SVG) | 64.02 KB | Preview | Download |
| BIOMD0000000688.vcml | Auto-generated VCML file | 910.00 Bytes | Preview | Download |
| BIOMD0000000688.xpp | Auto-generated XPP file | 8.24 KB | Preview | Download |
| BIOMD0000000688_urn.xml | Auto-generated SBML file with URNs | 109.78 KB | Preview | Download |
| MODEL1006230097.cps | Curated and annotated COPASI file | 127.13 KB | Preview | Download |
| MODEL1006230097.sedml | SED-ML file for figure 2b of the reference publication for t>100. | 1.65 KB | Preview | Download |
- Model originally submitted by : Camille Laibe
- Submitted: Jun 23, 2010 10:12:37 AM
- Last Modified: Mar 14, 2018 9:08:31 AM
Revisions
-
Version: 3
- Submitted on: Mar 14, 2018 9:08:31 AM
- Submitted by: administrator
- With comment: Model name updated using online editor.
-
Version: 2
- Submitted on: Jun 25, 2010 2:47:59 PM
- Submitted by: Camille Laibe
- With comment: Current version of Wodarz2007_CTLinflation_ModelC
-
Version: 1
- Submitted on: Jun 23, 2010 10:12:37 AM
- Submitted by: Camille Laibe
- With comment: Original import of Wodarz2007_CTLinflation_ModelC
(*) You might be seeing discontinuous
revisions as only public revisions are displayed here. Any private revisions
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: Variable used inside SBML models
| Species | Initial Concentration/Amount |
|---|---|
| y 1 cytomegalovirus infection ; infected cell |
0.0 mol |
| m 8 naive T cell |
0.0 mol |
| y 0 cytomegalovirus infection ; infected cell |
0.0 mol |
| m 7 naive T cell |
0.0 mol |
| m 3 naive T cell |
0.0 mol |
| m 4 naive T cell |
0.0 mol |
| z i natural killer cell ; natural killer cell |
0.1 mol |
| x cell ; Susceptibility ; cell |
1.0 mol |
| Reactions | Rate | Parameters |
|---|---|---|
| y_1 => ; z_a | COMpartment*pa*z_a*y_1 | pa = 1.0E-6 |
| m_8 => | COMpartment*r*m_8 | r = 1.0 |
| y_0 => y_1 | COMpartment*eta*y_0 | eta = 0.01 |
| y_1 => | COMpartment*a1*y_1 | a1 = 0.2 |
| m_7 => m_8 | COMpartment*r*m_7 | r = 1.0 |
| m_3 => m_4 | COMpartment*r*m_3 | r = 1.0 |
| => z_i | COMpartment*xi | xi = 0.01 |
| x => | COMpartment*d*x | d = 0.1 |
(added: 12 Mar 2018, 10:25:37, updated: 12 Mar 2018, 10:25:37)