Wodarz2007 - Basic Model of Cytomegalovirus Infection

  public model
Model Identifier
BIOMD0000000686
Short description

This a model from the article:
Dynamics of killer T cell inflation in viral infections.
Wodarz D, Sierro S, Klenerman P. J R Soc Interface 2007 Jun 22;4(14):533-43 17251133 ,
Abstract:
Upon acute viral infection, a typical cytotoxic T lymphocyte (CTL) response is characterized by a phase of expansion and contraction after which it settles at a relatively stable memory level. Recently, experimental data from mice infected with murine cytomegalovirus (MCMV) showed different and unusual dynamics. After acute infection had resolved, some antigen specific CTL started to expand over time despite the fact that no replicative virus was detectable. This phenomenon has been termed as "CTL memory inflation". In order to examine the dynamics of this system further, we developed a mathematical model analysing the impact of innate and adaptive immune responses. According to this model, a potentially important contributor to CTL inflation is competition between the specific CTL response and an innate natural killer (NK) cell response. Inflation occurs most readily if the NK cell response is more efficient than the CTL at reducing virus load during acute infection, but thereafter maintains a chronic virus load which is sufficient to induce CTL proliferation. The model further suggests that weaker NK cell mediated protection can correlate with more pronounced CTL inflation dynamics over time. We present experimental data from mice infected with MCMV which are consistent with the theoretical predictions. This model provides valuable information and may help to explain the inflation of CMV specific CD8+T cells seen in humans as they age.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Wodarz D, Sierro S, Klenerman P. (2007) - version=1.0
The original CellML model was created by:
Catherine Lloyd
c.lloyd@auckland.ac.nz
The University of Auckland

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not..

To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V4)
Related Publication
  • Dynamics of killer T cell inflation in viral infections.
  • Wodarz D, Sierro S, Klenerman P
  • Journal of the Royal Society, Interface , 6/ 2007 , Volume 4 , Issue 14 , pages: 533-543 , PubMed ID: 17251133
  • Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA. dwodarz@uci.edu
  • Upon acute viral infection, a typical cytotoxic T lymphocyte (CTL) response is characterized by a phase of expansion and contraction after which it settles at a relatively stable memory level. Recently, experimental data from mice infected with murine cytomegalovirus (MCMV) showed different and unusual dynamics. After acute infection had resolved, some antigen specific CTL started to expand over time despite the fact that no replicative virus was detectable. This phenomenon has been termed as "CTL memory inflation". In order to examine the dynamics of this system further, we developed a mathematical model analysing the impact of innate and adaptive immune responses. According to this model, a potentially important contributor to CTL inflation is competition between the specific CTL response and an innate natural killer (NK) cell response. Inflation occurs most readily if the NK cell response is more efficient than the CTL at reducing virus load during acute infection, but thereafter maintains a chronic virus load which is sufficient to induce CTL proliferation. The model further suggests that weaker NK cell mediated protection can correlate with more pronounced CTL inflation dynamics over time. We present experimental data from mice infected with MCMV which are consistent with the theoretical predictions. This model provides valuable information and may help to explain the inflation of CMV specific CD8+T cells seen in humans as they age.
Contributors
Submitter of the first revision: Camille Laibe
Submitter of this revision: administrator
Modellers: administrator, Camille Laibe

Metadata information

is (2 statements)
BioModels Database MODEL1006230086
BioModels Database BIOMD0000000686

isDescribedBy (2 statements)
PubMed 17251133
PubMed 17251133

hasTaxon (1 statement)
Taxonomy Mus

isVersionOf (1 statement)
Gene Ontology response to virus

occursIn (1 statement)
Brenda Tissue Ontology cytotoxic T-lymphocyte

Curation status
Curated
Tags

Connected external resources

SBGN view in Newt Editor

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Model files
BIOMD0000000686_url.xml SBML L2V4 representation of Wodarz2007 - Basic Model of Cytomegalovirus Infection 36.13 KB Preview | Download

Additional files
BIOMD0000000686-biopax2.owl Auto-generated BioPAX (Level 2) 3.62 KB Preview | Download
BIOMD0000000686-biopax3.owl Auto-generated BioPAX (Level 3) 3.71 KB Preview | Download
BIOMD0000000686.m Auto-generated Octave file 4.03 KB Preview | Download
BIOMD0000000686.pdf Auto-generated PDF file 141.12 KB Preview | Download
BIOMD0000000686.png Auto-generated Reaction graph (PNG) 4.27 KB Preview | Download
BIOMD0000000686.sci Auto-generated Scilab file 162.00 Bytes Preview | Download
BIOMD0000000686.svg Auto-generated Reaction graph (SVG) 845.00 Bytes Preview | Download
BIOMD0000000686.vcml Auto-generated VCML file 900.00 Bytes Preview | Download
BIOMD0000000686.xpp Auto-generated XPP file 1.95 KB Preview | Download
BIOMD0000000686_urn.xml Auto-generated SBML file with URNs 36.11 KB Preview | Download
MODEL1006230086.cps Annotated COPASI file 45.98 KB Preview | Download

  • Model originally submitted by : Camille Laibe
  • Submitted: Jun 23, 2010 10:12:31 AM
  • Last Modified: Mar 14, 2018 9:06:09 AM
Revisions
  • Version: 3 public model Download this version
    • Submitted on: Mar 14, 2018 9:06:09 AM
    • Submitted by: administrator
    • With comment: Model name updated using online editor.
  • Version: 2 public model Download this version
    • Submitted on: Jun 25, 2010 2:41:46 PM
    • Submitted by: Camille Laibe
    • With comment: Current version of Wodarz2007_CTLinflation_ModelA
  • Version: 1 public model Download this version
    • Submitted on: Jun 23, 2010 10:12:31 AM
    • Submitted by: Camille Laibe
    • With comment: Original import of Wodarz2007_CTLinflation_ModelA

(*) You might be seeing discontinuous revisions as only public revisions are displayed here. Any private revisions unpublished model revision of this model will only be shown to the submitter and their collaborators.

Curator's comment:
(added: 09 Mar 2018, 16:24:18, updated: 09 Mar 2018, 16:24:18)
The ODEs have been checked that they match with the system of ODEs listed in the publication, however there is no relevant figure to reproduce with this model.