Wodarz2003 - Immunological Memory
This a model from the article:
Evolution of immunological memory and the regulation of competition between
pathogens.
Wodarz D. Curr Biol
2003 Sep 16;13(18):1648-52 13678598
,
Abstract:
Memory is a central characteristic of immune responses. It is defined as an
elevated number of specific immune cells that remain after resolution of
infection and can protect the host against reinfection. The evolution of
immunological memory is subject to debate. The advantages of memory discussed so
far include protection from reinfection, control of chronic infection, and the
transfer of immune function to the next generation. Mathematical models are used
to identify a new force that can drive the evolution of immunological memory:
the duration of memory can regulate the degree of competition between different
pathogens. While a long duration of memory provides lasting protection against
reinfection, it may also allow an inferior pathogen species to persist. This can
be detrimental for the host if the inferior pathogen is more virulent. On the
other hand, a shorter duration of memory ensures that an inferior pathogen
species is excluded. This can be beneficial for the host if the inferior
pathogen is more virulent. Thus, while in the absence of pathogen diversity
memory is always expected to evolve to a long duration, under specific
circumstances, memory can evolve toward shorter durations in the presence of
pathogen diversity.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Wodarz D. (2003) - version=1.0
The original CellML model was created by:
Catherine Lloyd
c.lloyd@auckland.ac.nz
The University of Auckland
This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
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Evolution of immunological memory and the regulation of competition between pathogens.
- Wodarz D
- Current biology : CB , 9/ 2003 , Volume 13 , Issue 18 , pages: 1648-1652 , PubMed ID: 13678598
- Fred Hutchison Cancer Research Center, 1100 Fairview Avenue North, MP-665, Seattle, WA 98109, USA. wodarz@fhcrc.org
- Memory is a central characteristic of immune responses. It is defined as an elevated number of specific immune cells that remain after resolution of infection and can protect the host against reinfection. The evolution of immunological memory is subject to debate. The advantages of memory discussed so far include protection from reinfection, control of chronic infection, and the transfer of immune function to the next generation. Mathematical models are used to identify a new force that can drive the evolution of immunological memory: the duration of memory can regulate the degree of competition between different pathogens. While a long duration of memory provides lasting protection against reinfection, it may also allow an inferior pathogen species to persist. This can be detrimental for the host if the inferior pathogen is more virulent. On the other hand, a shorter duration of memory ensures that an inferior pathogen species is excluded. This can be beneficial for the host if the inferior pathogen is more virulent. Thus, while in the absence of pathogen diversity memory is always expected to evolve to a long duration, under specific circumstances, memory can evolve toward shorter durations in the presence of pathogen diversity.
Submitter of this revision: administrator
Modellers: administrator, Camille Laibe
Metadata information
isDescribedBy (2 statements)
hasTaxon (1 statement)
isVersionOf (1 statement)
Connected external resources
SBGN view in Newt Editor
| Name | Description | Size | Actions |
|---|---|---|---|
Model files |
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| BIOMD0000000684_url.xml | SBML L2V4 representation of Wodarz2003 - Immunological Memory | 56.33 KB | Preview | Download |
Additional files |
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| BIOMD0000000684-biopax2.owl | Auto-generated BioPAX (Level 2) | 3.28 KB | Preview | Download |
| BIOMD0000000684-biopax3.owl | Auto-generated BioPAX (Level 3) | 3.38 KB | Preview | Download |
| BIOMD0000000684.m | Auto-generated Octave file | 6.15 KB | Preview | Download |
| BIOMD0000000684.pdf | Auto-generated PDF file | 131.68 KB | Preview | Download |
| BIOMD0000000684.png | Auto-generated Reaction graph (PNG) | 4.27 KB | Preview | Download |
| BIOMD0000000684.sci | Auto-generated Scilab file | 178.00 Bytes | Preview | Download |
| BIOMD0000000684.svg | Auto-generated Reaction graph (SVG) | 845.00 Bytes | Preview | Download |
| BIOMD0000000684.vcml | Auto-generated VCML file | 900.00 Bytes | Preview | Download |
| BIOMD0000000684.xpp | Auto-generated XPP file | 3.46 KB | Preview | Download |
| BIOMD0000000684_urn.xml | Auto-generated SBML file with URNs | 56.31 KB | Preview | Download |
| MODEL1006230061.cps | Curated and annotated COPASI file. | 62.41 KB | Preview | Download |
| MODEL1006230061.sedml | SED-ML file for figure 2 of the reference publication. The value of k has been changed from 1 to 0.1. | 4.33 KB | Preview | Download |
- Model originally submitted by : Camille Laibe
- Submitted: Jun 23, 2010 10:12:19 AM
- Last Modified: Mar 8, 2018 4:38:01 PM
Revisions
-
Version: 3
- Submitted on: Mar 8, 2018 4:38:01 PM
- Submitted by: administrator
- With comment: Model name updated using online editor.
-
Version: 2
- Submitted on: Jun 25, 2010 2:23:00 PM
- Submitted by: Camille Laibe
- With comment: Current version of Wodarz2003_ImmunologicalMemory
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Version: 1
- Submitted on: Jun 23, 2010 10:12:19 AM
- Submitted by: Camille Laibe
- With comment: Original import of Wodarz2003_ImmunologicalMemory
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(added: 08 Mar 2018, 16:57:42, updated: 08 Mar 2018, 16:57:42)