Brown1997 - Plasma Melatonin Levels
This model is described in the article:
Abstract:
Studies in animals and humans suggest that the diurnal pattern in plasma melatonin levels is due to the hormone's rates of synthesis, circulatory infusion and clearance, circadian control of synthesis onset and offset, environmental lighting conditions, and error in the melatonin immunoassay. A two-dimensional linear differential equation model of the hormone is formulated and is used to analyze plasma melatonin levels in 18 normal healthy male subjects during a constant routine. Recently developed Bayesian statistical procedures are used to incorporate correctly the magnitude of the immunoassay error into the analysis. The estimated parameters [median (range)] were clearance half-life of 23.67 (14.79-59.93) min, synthesis onset time of 2206 (1940-0029), synthesis offset time of 0621 (0246-0817), and maximum N-acetyltransferase activity of 7.17(2.34-17.93) pmol x l(-1) x min(-1). All were in good agreement with values from previous reports. The difference between synthesis offset time and the phase of the core temperature minimum was 1 h 15 min (-4 h 38 min-2 h 43 min). The correlation between synthesis onset and the dim light melatonin onset was 0.93. Our model provides a more physiologically plausible estimate of the melatonin synthesis onset time than that given by the dim light melatonin onset and the first reliable means of estimating the phase of synthesis offset. Our analysis shows that the circadian and pharmacokinetics parameters of melatonin can be reliably estimated from a single model.
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A mathematical model of diurnal variations in human plasma melatonin levels.
- Brown EN, Choe Y, Shanahan TL, Czeisler CA
- The American journal of physiology , 3/ 1997 , Volume 272 , Issue 3 Pt 1 , pages: E506-16 , PubMed ID: 9124558
- Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
- Studies in animals and humans suggest that the diurnal pattern in plasma melatonin levels is due to the hormone's rates of synthesis, circulatory infusion and clearance, circadian control of synthesis onset and offset, environmental lighting conditions, and error in the melatonin immunoassay. A two-dimensional linear differential equation model of the hormone is formulated and is used to analyze plasma melatonin levels in 18 normal healthy male subjects during a constant routine. Recently developed Bayesian statistical procedures are used to incorporate correctly the magnitude of the immunoassay error into the analysis. The estimated parameters [median (range)] were clearance half-life of 23.67 (14.79-59.93) min, synthesis onset time of 2206 (1940-0029), synthesis offset time of 0621 (0246-0817), and maximum N-acetyltransferase activity of 7.17(2.34-17.93) pmol x l(-1) x min(-1). All were in good agreement with values from previous reports. The difference between synthesis offset time and the phase of the core temperature minimum was 1 h 15 min (-4 h 38 min-2 h 43 min). The correlation between synthesis onset and the dim light melatonin onset was 0.93. Our model provides a more physiologically plausible estimate of the melatonin synthesis onset time than that given by the dim light melatonin onset and the first reliable means of estimating the phase of synthesis offset. Our analysis shows that the circadian and pharmacokinetics parameters of melatonin can be reliably estimated from a single model.
Submitter of this revision: administrator
Modellers: administrator, Camille Laibe
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| BIOMD0000000672_url.xml | SBML L2V4 representation of Brown1997 - Plasma Melatonin Levels | 34.73 KB | Preview | Download |
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| BIOMD0000000672-biopax2.owl | Auto-generated BioPAX (Level 2) | 4.24 KB | Preview | Download |
| BIOMD0000000672-biopax3.owl | Auto-generated BioPAX (Level 3) | 4.33 KB | Preview | Download |
| BIOMD0000000672.m | Auto-generated Octave file | 3.43 KB | Preview | Download |
| BIOMD0000000672.pdf | Auto-generated PDF file | 135.03 KB | Preview | Download |
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| BIOMD0000000672.sci | Auto-generated Scilab file | 904.00 Bytes | Preview | Download |
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| BIOMD0000000672.vcml | Auto-generated VCML file | 900.00 Bytes | Preview | Download |
| BIOMD0000000672.xpp | Auto-generated XPP file | 2.22 KB | Preview | Download |
| BIOMD0000000672_urn.xml | Auto-generated SBML file with URNs | 34.69 KB | Preview | Download |
| MODEL1006230019.cps | Curated and annotated COPASI file. | 43.32 KB | Preview | Download |
| MODEL1006230019.sedml | SED-ML file to produce a simulation similar to simulations in figure 3 of the reference publication, using mean parameter values of parameter estimates for fitting data from 18 subjects. | 1.66 KB | Preview | Download |
- Model originally submitted by : Camille Laibe
- Submitted: Jun 23, 2010 10:11:58 AM
- Last Modified: Feb 14, 2018 9:45:34 AM
Revisions
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Version: 3
- Submitted on: Feb 14, 2018 9:45:34 AM
- Submitted by: administrator
- With comment: Current curated version of Brown1997_PlasmaMelatoninLevels
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Version: 2
- Submitted on: Jun 25, 2010 1:29:24 PM
- Submitted by: Camille Laibe
- With comment: Current version of Brown1997_PlasmaMelatoninLevels
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Version: 1
- Submitted on: Jun 23, 2010 10:11:58 AM
- Submitted by: Camille Laibe
- With comment: Original import of Brown1997_PlasmaMelatoninLevels
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(added: 14 Feb 2018, 09:39:14, updated: 14 Feb 2018, 09:39:14)