Brown1997 - Plasma Melatonin Levels

  public model
Model Identifier
BIOMD0000000672
Short description
Brown1997 - Plasma Melatonin Levels
A mathematical model that incorporates a piecewise function for NAT activity to predict melatonin concentration.

This model is described in the article:

Brown EN, Choe Y, Shanahan TL, Czeisler CA.
Am. J. Physiol. 1997 Mar; 272(3 Pt 1): E506-16

Abstract:

Studies in animals and humans suggest that the diurnal pattern in plasma melatonin levels is due to the hormone's rates of synthesis, circulatory infusion and clearance, circadian control of synthesis onset and offset, environmental lighting conditions, and error in the melatonin immunoassay. A two-dimensional linear differential equation model of the hormone is formulated and is used to analyze plasma melatonin levels in 18 normal healthy male subjects during a constant routine. Recently developed Bayesian statistical procedures are used to incorporate correctly the magnitude of the immunoassay error into the analysis. The estimated parameters [median (range)] were clearance half-life of 23.67 (14.79-59.93) min, synthesis onset time of 2206 (1940-0029), synthesis offset time of 0621 (0246-0817), and maximum N-acetyltransferase activity of 7.17(2.34-17.93) pmol x l(-1) x min(-1). All were in good agreement with values from previous reports. The difference between synthesis offset time and the phase of the core temperature minimum was 1 h 15 min (-4 h 38 min-2 h 43 min). The correlation between synthesis onset and the dim light melatonin onset was 0.93. Our model provides a more physiologically plausible estimate of the melatonin synthesis onset time than that given by the dim light melatonin onset and the first reliable means of estimating the phase of synthesis offset. Our analysis shows that the circadian and pharmacokinetics parameters of melatonin can be reliably estimated from a single model.

This model is hosted on BioModels Database and identified by: BIOMD0000000672.

To cite BioModels Database, please use: Chelliah V et al. BioModels: ten-year anniversary. Nucl. Acids Res. 2015, 43(Database issue):D542-8.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Format
SBML (L2V4)
Related Publication
  • A mathematical model of diurnal variations in human plasma melatonin levels.
  • Brown EN, Choe Y, Shanahan TL, Czeisler CA
  • The American journal of physiology , 3/ 1997 , Volume 272 , Issue 3 Pt 1 , pages: E506-16 , PubMed ID: 9124558
  • Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
  • Studies in animals and humans suggest that the diurnal pattern in plasma melatonin levels is due to the hormone's rates of synthesis, circulatory infusion and clearance, circadian control of synthesis onset and offset, environmental lighting conditions, and error in the melatonin immunoassay. A two-dimensional linear differential equation model of the hormone is formulated and is used to analyze plasma melatonin levels in 18 normal healthy male subjects during a constant routine. Recently developed Bayesian statistical procedures are used to incorporate correctly the magnitude of the immunoassay error into the analysis. The estimated parameters [median (range)] were clearance half-life of 23.67 (14.79-59.93) min, synthesis onset time of 2206 (1940-0029), synthesis offset time of 0621 (0246-0817), and maximum N-acetyltransferase activity of 7.17(2.34-17.93) pmol x l(-1) x min(-1). All were in good agreement with values from previous reports. The difference between synthesis offset time and the phase of the core temperature minimum was 1 h 15 min (-4 h 38 min-2 h 43 min). The correlation between synthesis onset and the dim light melatonin onset was 0.93. Our model provides a more physiologically plausible estimate of the melatonin synthesis onset time than that given by the dim light melatonin onset and the first reliable means of estimating the phase of synthesis offset. Our analysis shows that the circadian and pharmacokinetics parameters of melatonin can be reliably estimated from a single model.
Contributors
Submitter of the first revision: Camille Laibe
Submitter of this revision: administrator
Modellers: administrator, Camille Laibe

Metadata information

is (2 statements)
BioModels Database MODEL1006230019
BioModels Database BIOMD0000000672

isDescribedBy (1 statement)
PubMed 9124558

hasTaxon (1 statement)
Taxonomy Homo sapiens

isVersionOf (1 statement)
hasProperty (1 statement)
Gene Ontology circadian rhythm

hasPart (2 statements)
NCIt Melatonin
ChEBI melatonin


Curation status
Curated

Tags

Connected external resources

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Model files

BIOMD0000000672_url.xml SBML L2V4 representation of Brown1997 - Plasma Melatonin Levels 34.73 KB Preview | Download

Additional files

BIOMD0000000672-biopax2.owl Auto-generated BioPAX (Level 2) 4.24 KB Preview | Download
BIOMD0000000672-biopax3.owl Auto-generated BioPAX (Level 3) 4.33 KB Preview | Download
BIOMD0000000672.m Auto-generated Octave file 3.43 KB Preview | Download
BIOMD0000000672.pdf Auto-generated PDF file 135.03 KB Preview | Download
BIOMD0000000672.png Auto-generated Reaction graph (PNG) 4.27 KB Preview | Download
BIOMD0000000672.sci Auto-generated Scilab file 904.00 Bytes Preview | Download
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BIOMD0000000672.vcml Auto-generated VCML file 900.00 Bytes Preview | Download
BIOMD0000000672.xpp Auto-generated XPP file 2.22 KB Preview | Download
BIOMD0000000672_urn.xml Auto-generated SBML file with URNs 34.69 KB Preview | Download
MODEL1006230019.cps Curated and annotated COPASI file. 43.32 KB Preview | Download
MODEL1006230019.sedml SED-ML file to produce a simulation similar to simulations in figure 3 of the reference publication, using mean parameter values of parameter estimates for fitting data from 18 subjects. 1.66 KB Preview | Download

  • Model originally submitted by : Camille Laibe
  • Submitted: Jun 23, 2010 10:11:58 AM
  • Last Modified: Feb 14, 2018 9:45:34 AM
Revisions
  • Version: 3 public model Download this version
    • Submitted on: Feb 14, 2018 9:45:34 AM
    • Submitted by: administrator
    • With comment: Current curated version of Brown1997_PlasmaMelatoninLevels
  • Version: 2 public model Download this version
    • Submitted on: Jun 25, 2010 1:29:24 PM
    • Submitted by: Camille Laibe
    • With comment: Current version of Brown1997_PlasmaMelatoninLevels
  • Version: 1 public model Download this version
    • Submitted on: Jun 23, 2010 10:11:58 AM
    • Submitted by: Camille Laibe
    • With comment: Original import of Brown1997_PlasmaMelatoninLevels

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Curator's comment:
(added: 14 Feb 2018, 09:39:14, updated: 14 Feb 2018, 09:39:14)
Simulation of plasma melatonin concentration using the mean parameter value estimates obtained from fitting models to data of 18 subjects (Figure 3 of reference publication). COPASI 4.22 (Build 170) was used for the simulation and figure generation.