Jelic2005_HypothalamicPituitaryAdrenal

  public model
Model Identifier
MODEL1006230013
Short description

This a model from the article:
Mathematical modeling of the hypothalamic-pituitary-adrenal system activity.
Jelic S, Cupic Z, Kolar-Anic L. Math Biosci 2005 Oct;197(2):173-87 16112688 ,
Abstract:
Mathematical modeling has proven to be valuable in understanding of the complex biological systems dynamics. In the present report we have developed an initial model of the hypothalamic-pituitary-adrenal system self-regulatory activity. A four-dimensional non-linear differential equation model of the hormone secretion was formulated and used to analyze plasma cortisol levels in humans. The aim of this work was to explore in greater detail the role of this system in normal, homeostatic, conditions, since it is the first and unavoidable step in further understanding of the role of this complex neuroendocrine system in pathophysiological conditions. Neither the underlying mechanisms nor the physiological significance of this system are fully understood yet.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Jelic S, Cupic Z, Kolar-Anic L. (2005) - version=1.0
The original CellML model was created by:
Catherine Lloyd
c.lloyd@auckland.ac.nz
The University of Auckland

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not..

To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V4)
Related Publication
  • Mathematical modeling of the hypothalamic-pituitary-adrenal system activity.
  • Jelić S, Cupić Z, Kolar-Anić L
  • Mathematical biosciences , 10/ 2005 , Volume 197 , pages: 173-187 , PubMed ID: 16112688
  • Department of Theoretical Physics and Physics of Condensed Matter 020/2, Vinca Institute of Nuclear Sciences, P.O. Box 522, 11001 Belgrade, Serbia and Montenegro. jelic@vin.bg.ac.yu
  • Mathematical modeling has proven to be valuable in understanding of the complex biological systems dynamics. In the present report we have developed an initial model of the hypothalamic-pituitary-adrenal system self-regulatory activity. A four-dimensional non-linear differential equation model of the hormone secretion was formulated and used to analyze plasma cortisol levels in humans. The aim of this work was to explore in greater detail the role of this system in normal, homeostatic, conditions, since it is the first and unavoidable step in further understanding of the role of this complex neuroendocrine system in pathophysiological conditions. Neither the underlying mechanisms nor the physiological significance of this system are fully understood yet.
Contributors
Submitter of the first revision: Camille Laibe
Submitter of this revision: Camille Laibe
Modellers: Camille Laibe

Metadata information

is (1 statement)
BioModels Database MODEL1006230013

isDescribedBy (1 statement)
PubMed 16112688

hasTaxon (1 statement)
Taxonomy Homo sapiens

isVersionOf (1 statement)
Gene Ontology cortisol secretion

hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model


Curation status
Non-curated


Original model(s)
http://models.cellml.org/exposure/4817bdfdd245412f52dd79da59137fe8

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MODEL1006230013_urn.xml Auto-generated SBML file with URNs 14.91 KB Preview | Download

  • Model originally submitted by : Camille Laibe
  • Submitted: Jun 23, 2010 10:11:55 AM
  • Last Modified: Jun 25, 2010 1:24:01 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Jun 25, 2010 1:24:01 PM
    • Submitted by: Camille Laibe
    • With comment: Current version of Jelic2005_HypothalamicPituitaryAdrenal
  • Version: 1 public model Download this version
    • Submitted on: Jun 23, 2010 10:11:55 AM
    • Submitted by: Camille Laibe
    • With comment: Original import of Jelic2005_HypothalamicPituitaryAdrenal

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