Jelic2005_HypothalamicPituitaryAdrenal

This a model from the article:
Mathematical modeling of the hypothalamic-pituitary-adrenal system activity.
Jelic S, Cupic Z, Kolar-Anic L. Math Biosci
2005 Oct;197(2):173-87 16112688
,
Abstract:
Mathematical modeling has proven to be valuable in understanding of the complex
biological systems dynamics. In the present report we have developed an initial
model of the hypothalamic-pituitary-adrenal system self-regulatory activity. A
four-dimensional non-linear differential equation model of the hormone secretion
was formulated and used to analyze plasma cortisol levels in humans. The aim of
this work was to explore in greater detail the role of this system in normal,
homeostatic, conditions, since it is the first and unavoidable step in further
understanding of the role of this complex neuroendocrine system in
pathophysiological conditions. Neither the underlying mechanisms nor the
physiological significance of this system are fully understood yet.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Jelic S, Cupic Z, Kolar-Anic L. (2005) - version=1.0
The original CellML model was created by:
Catherine Lloyd
c.lloyd@auckland.ac.nz
The University of Auckland
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
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Mathematical modeling of the hypothalamic-pituitary-adrenal system activity.
- Jelić S, Cupić Z, Kolar-Anić L
- Mathematical biosciences , 10/ 2005 , Volume 197 , pages: 173-187 , PubMed ID: 16112688
- Department of Theoretical Physics and Physics of Condensed Matter 020/2, Vinca Institute of Nuclear Sciences, P.O. Box 522, 11001 Belgrade, Serbia and Montenegro. jelic@vin.bg.ac.yu
- Mathematical modeling has proven to be valuable in understanding of the complex biological systems dynamics. In the present report we have developed an initial model of the hypothalamic-pituitary-adrenal system self-regulatory activity. A four-dimensional non-linear differential equation model of the hormone secretion was formulated and used to analyze plasma cortisol levels in humans. The aim of this work was to explore in greater detail the role of this system in normal, homeostatic, conditions, since it is the first and unavoidable step in further understanding of the role of this complex neuroendocrine system in pathophysiological conditions. Neither the underlying mechanisms nor the physiological significance of this system are fully understood yet.
Submitter of this revision: Camille Laibe
Modellers: Camille Laibe
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- Model originally submitted by : Camille Laibe
- Submitted: Jun 23, 2010 10:11:55 AM
- Last Modified: Jun 25, 2010 1:24:01 PM
Revisions
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Version: 2
- Submitted on: Jun 25, 2010 1:24:01 PM
- Submitted by: Camille Laibe
- With comment: Current version of Jelic2005_HypothalamicPituitaryAdrenal
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Version: 1
- Submitted on: Jun 23, 2010 10:11:55 AM
- Submitted by: Camille Laibe
- With comment: Original import of Jelic2005_HypothalamicPituitaryAdrenal
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