Tolic2000_InsulinGlucoseFeedback

  public model
Short description

This a model from the article:
Modeling the insulin-glucose feedback system: the significance of pulsatile insulin secretion.
Tolic IM, Mosekilde E, Sturis J. J Theor Biol2000 Dec 7;207(3):361-75 11082306,
Abstract:
A mathematical model of the insulin-glucose feedback regulation in man is used to examine the effects of an oscillatory supply of insulin compared to a constant supply at the same average rate. We show that interactions between the oscillatory insulin supply and the receptor dynamics can be of minute significance only. It is possible, however, to interpret seemingly conflicting results of clinical studies in terms of their different experimental conditions with respect to the hepatic glucose release. If this release is operating near an upper limit, an oscillatory insulin supply will be more efficient in lowering the blood glucose level than a constant supply. If the insulin level is high enough for the hepatic release of glucose to nearly vanish, the opposite effect is observed. For insulin concentrations close to the point of inflection of the insulin-glucose dose-response curve an oscillatory and a constant insulin infusion produce similar effects. Copyright 2000 Academic Press.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Tolic IM, Mosekilde E, Sturis J. (2000) - version=1.0

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
For more information see the terms of use.
To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V4)
Related Publication
  • Modeling the insulin-glucose feedback system: the significance of pulsatile insulin secretion.
  • Tolić IM, Mosekilde E, Sturis J
  • Journal of theoretical biology , 12/ 2000 , Volume 207 , pages: 361-375
  • The Rugjer Boskovic Institute, Zagreb, Croatia. itolic@hsph.harvard.edu
  • A mathematical model of the insulin-glucose feedback regulation in man is used to examine the effects of an oscillatory supply of insulin compared to a constant supply at the same average rate. We show that interactions between the oscillatory insulin supply and the receptor dynamics can be of minute significance only. It is possible, however, to interpret seemingly conflicting results of clinical studies in terms of their different experimental conditions with respect to the hepatic glucose release. If this release is operating near an upper limit, an oscillatory insulin supply will be more efficient in lowering the blood glucose level than a constant supply. If the insulin level is high enough for the hepatic release of glucose to nearly vanish, the opposite effect is observed. For insulin concentrations close to the point of inflection of the insulin-glucose dose-response curve an oscillatory and a constant insulin infusion produce similar effects.
Contributors
Camille Laibe

Metadata information

is
BioModels Database MODEL1006230109
BioModels Database BIOMD0000000372
isDerivedFrom
BioModels Database BIOMD0000000382
isDescribedBy
PubMed 11082306
hasTaxon
Taxonomy Homo sapiens
occursIn
Brenda Tissue Ontology pancreatic beta cell
hasProperty
Human Disease Ontology diabetes mellitus
Curation status
Curated
Original model(s)
http://models.cellml.org/exposure/10b77d1cbab9074acfeb8170832760fb
Name Description Size Actions

Model file

BIOMD0000000372_url.xml SBML L2V4 representation of Tolic2000_InsulinGlucoseFeedback 19.55 KB Preview | Download

Additional files

BIOMD0000000372.m Auto-generated Octave file 5.98 KB Preview | Download
BIOMD0000000372.png Auto-generated Reaction graph (PNG) 5.04 KB Preview | Download
BIOMD0000000372-biopax3.owl Auto-generated BioPAX (Level 3) 5.97 KB Preview | Download
BIOMD0000000372-biopax2.owl Auto-generated BioPAX (Level 2) 5.33 KB Preview | Download
BIOMD0000000372.svg Auto-generated Reaction graph (SVG) 851.00 bytes Preview | Download
BIOMD0000000372.pdf Auto-generated PDF file 154.78 KB Preview | Download
BIOMD0000000372.xpp Auto-generated XPP file 3.74 KB Preview | Download
BIOMD0000000372_urn.xml Auto-generated SBML file with URNs 19.39 KB Preview | Download
BIOMD0000000372.vcml Auto-generated VCML file 900.00 bytes Preview | Download
BIOMD0000000372.sci Auto-generated Scilab file 158.00 bytes Preview | Download

  • Model originally submitted by : Camille Laibe
  • Submitted: 23-Jun-2010 10:12:44
  • Last Modified: 10-Oct-2014 11:30:40
Revisions
  • Version: 2 public model Download this version
    • Submitted on: 10-Oct-2014 11:30:40
    • Submitted by: Camille Laibe
    • With comment: Current version of Tolic2000_InsulinGlucoseFeedback
  • Version: 1 public model Download this version
    • Submitted on: 23-Jun-2010 10:12:44
    • Submitted by: Camille Laibe
    • With comment: Original import of Tolic2000_InsulinGlucoseFeedback
Curator's comment:
(added: 28 Sep 2011, 23:51:33, updated: 28 Sep 2011, 23:51:33)
The model reproduces fig 1 of the reference publication. The model was integrated and simulated using Copasi v4.7 (Build 34).