Model Identifier
BIOMD0000000079
Short description

This model is according to the paper of A model for the dynamics of human weight cycling by A. Goldbeter 2006.The figure3 (A) and (B) have been reproduced by Copasi 4.0.19(development) and SBMLodeSolver.The writer of the paper did not specify any units for the metabolites, so the creator of the model did not define the units as well.Both Q and R are normalized to vary between 0 and 1.


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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V4)
Related Publication
  • A model for the dynamics of human weight cycling.
  • Goldbeter A
  • Journal of biosciences , 3/ 2006 , Volume 31 , pages: 129-136 , PubMed ID: 16595882
  • Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, Brussels, Belgium. agoldbet@ulb.ac.be
  • The resolution to lose weight by cognitive restraint of nutritional intake often leads to repeated bouts of weight loss and regain, a phenomenon known as weight cycling or "yo-yo dieting". A simple mathematical model for weight cycling is presented. The model is based on a feedback of psychological nature by which a subject decides to reduce dietary intake once a threshold weight is exceeded. The analysis of the model indicates that sustained oscillations in body weight occur in a parameter range bounded by critical values. Only outside this range can body weight reach a stable steady state. The model provides a theoretical framework that captures key facets of weight cycling and suggests ways to control the phenomenon. The view that weight cycling represents self-sustained oscillations has indeed specific implications. In dynamical terms, to bring weight cycling to an end, parameter values should change in such a way as to induce the transition of body weight from sustained oscillations around an unstable steady state to a stable steady state. Maintaining weight under a critical value should prevent weight cycling and allow body weight to stabilize below the oscillatory range.
Contributors
Enuo He

Metadata information

is
BioModels Database MODEL4644593552
BioModels Database BIOMD0000000079
isDescribedBy
PubMed 16595882
hasTaxon
Taxonomy Homo sapiens

Curation status
Curated

Tags
Name Description Size Actions

Model files

BIOMD0000000079_url.xml SBML L2V4 representation of Goldbeter2006_weightCycling 16.34 KB Preview | Download

Additional files

BIOMD0000000079.xpp Auto-generated XPP file 2.37 KB Preview | Download
BIOMD0000000079.vcml Auto-generated VCML file 976.00 bytes Preview | Download
BIOMD0000000079.pdf Auto-generated PDF file 157.59 KB Preview | Download
BIOMD0000000079-biopax3.owl Auto-generated BioPAX (Level 3) 11.88 KB Preview | Download
BIOMD0000000079_urn.xml Auto-generated SBML file with URNs 16.13 KB Preview | Download
BIOMD0000000079.svg Auto-generated Reaction graph (SVG) 11.68 KB Preview | Download
BIOMD0000000079-biopax2.owl Auto-generated BioPAX (Level 2) 8.96 KB Preview | Download
BIOMD0000000079.png Auto-generated Reaction graph (PNG) 23.39 KB Preview | Download
BIOMD0000000079.m Auto-generated Octave file 4.35 KB Preview | Download
BIOMD0000000079.sci Auto-generated Scilab file 1.65 KB Preview | Download

  • Model originally submitted by : Enuo He
  • Submitted: 27-Nov-2006 17:01:16
  • Last Modified: 25-Feb-2015 11:30:27
Revisions
  • Version: 2 public model Download this version
    • Submitted on: 25-Feb-2015 11:30:27
    • Submitted by: Enuo He
    • With comment: Current version of Goldbeter2006_weightCycling
  • Version: 1 public model Download this version
    • Submitted on: 27-Nov-2006 17:01:16
    • Submitted by: Enuo He
    • With comment: Original import of Goldbeter2006_weightCycling
Legends
: Variable used inside SBML models


Species
Species Initial Concentration/Amount
P 0.43 dimensionless
R 0.55 dimensionless
Q 0.8 dimensionless
Reactions
Reactions Rate Parameters
body*a*Q

body*a*Q
a=0.1
V*P/(Km+P)

V*P/(Km+P)
V=0.1; Km=0.2
P*V3*(1-R)/(k3+(1-R))

P*V3*(1-R)/(k3+(1-R))
k3=0.01; V3=6.0
V1*(1-Q)/(K1+(1-Q))

V1*(1-Q)/(K1+(1-Q))
K1=0.01; V1=1.0
V2*R*Q/(K2+Q)

V2*R*Q/(K2+Q)
K2=0.01; V2=1.5
V*R/(Km+R)

V*R/(Km+R)
V=2.5; Km=0.01
Curator's comment:
(added: 18 Jan 2010, 11:37:07, updated: 18 Jan 2010, 11:37:07)
Reproduction of figures 3 A and B from the original publication using Copasi 4.5. The units in fig 3 are not correct.