Goldbeter2006_weightCyclingView the 2007-08 Model of the Month entry for this model
This model is according to the paper of A model for the dynamics of human weight cycling by A. Goldbeter 2006.The figure3 (A) and (B) have been reproduced by Copasi 4.0.19(development) and SBMLodeSolver.The writer of the paper did not specify any units for the metabolites, so the creator of the model did not define the units as well.Both Q and R are normalized to vary between 0 and 1.
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- A model for the dynamics of human weight cycling.
- Goldbeter A
- Journal of biosciences , 3/ 2006 , Volume 31 , pages: 129-136 , PubMed ID: 16595882
- Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, Brussels, Belgium. firstname.lastname@example.org
- The resolution to lose weight by cognitive restraint of nutritional intake often leads to repeated bouts of weight loss and regain, a phenomenon known as weight cycling or "yo-yo dieting". A simple mathematical model for weight cycling is presented. The model is based on a feedback of psychological nature by which a subject decides to reduce dietary intake once a threshold weight is exceeded. The analysis of the model indicates that sustained oscillations in body weight occur in a parameter range bounded by critical values. Only outside this range can body weight reach a stable steady state. The model provides a theoretical framework that captures key facets of weight cycling and suggests ways to control the phenomenon. The view that weight cycling represents self-sustained oscillations has indeed specific implications. In dynamical terms, to bring weight cycling to an end, parameter values should change in such a way as to induce the transition of body weight from sustained oscillations around an unstable steady state to a stable steady state. Maintaining weight under a critical value should prevent weight cycling and allow body weight to stabilize below the oscillatory range.
|BIOMD0000000079_url.xml||SBML L2V4 representation of Goldbeter2006_weightCycling||16.34 KB||Preview | Download|
|BIOMD0000000079.xpp||Auto-generated XPP file||2.37 KB||Preview | Download|
|BIOMD0000000079.vcml||Auto-generated VCML file||976.00 bytes||Preview | Download|
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|BIOMD0000000079-biopax3.owl||Auto-generated BioPAX (Level 3)||11.88 KB||Preview | Download|
|BIOMD0000000079_urn.xml||Auto-generated SBML file with URNs||16.13 KB||Preview | Download|
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- Model originally submitted by : Enuo He
- Submitted: 27-Nov-2006 17:01:16
- Last Modified: 25-Feb-2015 11:30:27
: Variable used inside SBML models
(added: 18 Jan 2010, 11:37:07, updated: 18 Jan 2010, 11:37:07)