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This model was successfully tested on Jarnac and MathSBML. The model reproduces the time profile of "Open Probability" of the receptor as shown in Figure 4 of the publication. The value of calcium ion concentration "c" in this model is 10 microM.

Related Publication
  • A dynamic model of the type-2 inositol trisphosphate receptor.
  • Sneyd J, Dufour JF
  • Proceedings of the National Academy of Sciences of the United States of America , 2/ 2002 , Volume 99 , pages: 2398-2403 , PubMed ID: 11842185
  • Institute of Information and Mathematical Sciences, Massey University, Albany Campus, Private Bag 102-904, North Shore Mail Centre, Auckland, New Zealand.
  • The dynamic properties of the inositol (1,4,5)-trisphosphate (IP(3)) receptor are crucial for the control of intracellular Ca(2+), including the generation of Ca(2+) oscillations and waves. However, many models of this receptor do not agree with recent experimental data on the dynamic responses of the receptor. We construct a model of the IP(3) receptor and fit the model to dynamic and steady-state experimental data from type-2 IP(3) receptors. Our results indicate that, (i) Ca(2+) binds to the receptor using saturating, not mass-action, kinetics; (ii) Ca(2+) decreases the rate of IP(3) binding while simultaneously increasing the steady-state sensitivity of the receptor to IP(3); (iii) the rate of Ca(2+)-induced receptor activation increases with Ca(2+) and is faster than Ca(2+)-induced receptor inactivation; and (iv) IP(3) receptors are sequentially activated and inactivated by Ca(2+) even when IP(3) is bound. Our results emphasize that measurement of steady-state properties alone is insufficient to characterize the functional properties of the receptor.
Harish Dharuri

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BIOMD0000000057.xml.origin SBML L2V1 representation of Sneyd2002_IP3_Receptor 19.69 KB Preview | Download

  • Model originally submitted by : Harish Dharuri
  • Submitted: Jun 8, 2006 9:05:15 AM
  • Last Modified: Feb 24, 2015 8:32:18 PM
  • Version: 2 public model Download this version
    • Submitted on: Feb 24, 2015 8:32:18 PM
    • Submitted by: Harish Dharuri
    • With comment: Current version of Sneyd2002_IP3_Receptor
  • Version: 1 public model Download this version
    • Submitted on: Jun 8, 2006 9:05:15 AM
    • Submitted by: Harish Dharuri
    • With comment: Original import of Sneyd2002_IP3_Receptor

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Curator's comment:
(added: 18 Dec 2006, 22:37:15, updated: 18 Dec 2006, 22:37:15)
Time profile of Open probability of the IP3 receptor as shown in Fig 4 of the paper. The plot corresponds to a calcium ion concentration of 10 microMolars. Simulation result from Jarnac.