This model was successfully tested on Jarnac and MathSBML. The model reproduces the time profile of "Open Probability" of the receptor as shown in Figure 4 of the publication. The value of calcium ion concentration "c" in this model is 10 microM.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
- A dynamic model of the type-2 inositol trisphosphate receptor.
- Sneyd J, Dufour JF
- Proceedings of the National Academy of Sciences of the United States of America , 2/ 2002 , Volume 99 , pages: 2398-2403 , PubMed ID: 11842185
- Institute of Information and Mathematical Sciences, Massey University, Albany Campus, Private Bag 102-904, North Shore Mail Centre, Auckland, New Zealand. firstname.lastname@example.org
- The dynamic properties of the inositol (1,4,5)-trisphosphate (IP(3)) receptor are crucial for the control of intracellular Ca(2+), including the generation of Ca(2+) oscillations and waves. However, many models of this receptor do not agree with recent experimental data on the dynamic responses of the receptor. We construct a model of the IP(3) receptor and fit the model to dynamic and steady-state experimental data from type-2 IP(3) receptors. Our results indicate that, (i) Ca(2+) binds to the receptor using saturating, not mass-action, kinetics; (ii) Ca(2+) decreases the rate of IP(3) binding while simultaneously increasing the steady-state sensitivity of the receptor to IP(3); (iii) the rate of Ca(2+)-induced receptor activation increases with Ca(2+) and is faster than Ca(2+)-induced receptor inactivation; and (iv) IP(3) receptors are sequentially activated and inactivated by Ca(2+) even when IP(3) is bound. Our results emphasize that measurement of steady-state properties alone is insufficient to characterize the functional properties of the receptor.
|BIOMD0000000057_url.xml||SBML L2V1 representation of Sneyd2002_IP3_Receptor||26.60 KB||Preview | Download|
|BIOMD0000000057-biopax2.owl||Auto-generated BioPAX (Level 2)||10.63 KB||Preview | Download|
|BIOMD0000000057.vcml||Auto-generated VCML file||24.40 KB||Preview | Download|
|BIOMD0000000057-biopax3.owl||Auto-generated BioPAX (Level 3)||14.96 KB||Preview | Download|
|BIOMD0000000057.m||Auto-generated Octave file||6.87 KB||Preview | Download|
|BIOMD0000000057.xpp||Auto-generated XPP file||4.61 KB||Preview | Download|
|BIOMD0000000057.svg||Auto-generated Reaction graph (SVG)||12.63 KB||Preview | Download|
|BIOMD0000000057_urn.xml||Auto-generated SBML file with URNs||26.05 KB||Preview | Download|
|BIOMD0000000057.png||Auto-generated Reaction graph (PNG)||23.64 KB||Preview | Download|
|BIOMD0000000057.sci||Auto-generated Scilab file||3.88 KB||Preview | Download|
|BIOMD0000000057.pdf||Auto-generated PDF file||163.69 KB||Preview | Download|
- Model originally submitted by : Harish Dharuri
- Submitted: Jun 8, 2006 9:05:15 AM
- Last Modified: Feb 24, 2015 8:32:18 PM
- Submitted on: Feb 24, 2015 8:32:18 PM
- Submitted by: Harish Dharuri
- With comment: Current version of Sneyd2002_IP3_Receptor
- Submitted on: Jun 8, 2006 9:05:15 AM
- Submitted by: Harish Dharuri
- With comment: Original import of Sneyd2002_IP3_Receptor
(*) You might be seeing discontinuous revisions as only public revisions are displayed here. Any private revisions of this model will only be shown to the submitter and their collaborators.
: Variable used inside SBML models
|A => I2||compartment*(Phi5*A-(kminus1+lminus2)*I2)||lminus2 = 0.8; kminus1 = 0.04; lminus2=0.8; kminus1=0.04; Phi5 = 0.0|
|R => I1||compartment*(Phi1*R-(kminus1+lminus2)*I1)||lminus2 = 0.8; kminus1 = 0.04; Phi1 = 0.0; lminus2=0.8; kminus1=0.04|
|R => O||compartment*(Phi2*IP3*R-Phi_minus2*O)||IP3=10.0; IP3 = 10.0; Phi_minus2 = 0.0; Phi2 = 0.0|
|O => S||compartment*(Phi3*O-kminus3*S)||kminus3 = 29.8; kminus3=29.8; Phi3 = 0.0|
|O => A||compartment*(Phi4*O-Phi_minus4*A)||Phi4 = 0.0; Phi_minus4 = 0.0|
(added: 18 Dec 2006, 22:37:15, updated: 18 Dec 2006, 22:37:15)