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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Related Publication
  • A model for circadian oscillations in the Drosophila period protein (PER).
  • Goldbeter A
  • Proceedings. Biological sciences , 9/ 1995 , Volume 261 , pages: 319-324 , PubMed ID: 8587874
  • Faculté des Sciences, Université Libre de Bruxelles, Brussels, Belgium.
  • The mechanism of circadian oscillations in the period protein (PER) in Drosophila is investigated by means of a theoretical model. Taking into account recent experimental observations, the model for the circadian clock is based on multiple phosphorylation of PER and on the negative feedback exerted by PER on the transcription of the period (per) gene. This minimal biochemical model provides a molecular basis for circadian oscillations of the limit cycle type. During oscillations, the peak in per mRNA precedes by several hours the peak in total PER protein. The results support the view that multiple PER phosphorylation introduces times delays which strengthen the capability of negative feedback to produce oscillations. The analysis shows that the rhythm only occurs in a range bounded by two critical values of the maximum rate of PER degradation. A similar result is obtained with respect to the rate of PER transport into the nucleus. The results suggest a tentative explanation for the altered period of per mutants, in terms of variations in the rate of PER degradation.
Submitter of the first revision: Nicolas Le Novère
Submitter of this revision: Nicolas Le Novère
Modellers: Nicolas Le Novère

Metadata information

is (3 statements)
BioModels Database MODEL6617161845
BioModels Database BIOMD0000000016
KEGG Pathway dme04710

isDescribedBy (1 statement)
PubMed 8587874

hasTaxon (1 statement)
isVersionOf (1 statement)

Curation status


Connected external resources

SBGN view in Newt Editor

Name Description Size Actions

Model files

BIOMD0000000016_url.xml SBML L2V1 representation of Goldbeter1995_CircClock 28.40 KB Preview | Download

Additional files

BIOMD0000000016-biopax2.owl Auto-generated BioPAX (Level 2) 18.42 KB Preview | Download
BIOMD0000000016-biopax3.owl Auto-generated BioPAX (Level 3) 26.69 KB Preview | Download
BIOMD0000000016.m Auto-generated Octave file 6.04 KB Preview | Download
BIOMD0000000016.pdf Auto-generated PDF file 182.03 KB Preview | Download
BIOMD0000000016.png Auto-generated Reaction graph (PNG) 51.44 KB Preview | Download
BIOMD0000000016.sci Auto-generated Scilab file 3.29 KB Preview | Download
BIOMD0000000016.svg Auto-generated Reaction graph (SVG) 21.83 KB Preview | Download
BIOMD0000000016.vcml Auto-generated VCML file 881.00 Bytes Preview | Download
BIOMD0000000016.xpp Auto-generated XPP file 3.51 KB Preview | Download
BIOMD0000000016_urn.xml Auto-generated SBML file with URNs 27.84 KB Preview | Download

  • Model originally submitted by : Nicolas Le Novère
  • Submitted: Sep 13, 2005 2:13:05 PM
  • Last Modified: Feb 25, 2015 1:08:26 PM
  • Version: 2 public model Download this version
    • Submitted on: Feb 25, 2015 1:08:26 PM
    • Submitted by: Nicolas Le Novère
    • With comment: Current version of Goldbeter1995_CircClock
  • Version: 1 public model Download this version
    • Submitted on: Sep 13, 2005 2:13:05 PM
    • Submitted by: Nicolas Le Novère
    • With comment: Original import of Goldbeter1995_CircClock

(*) You might be seeing discontinuous revisions as only public revisions are displayed here. Any private revisions unpublished model revision of this model will only be shown to the submitter and their collaborators.

: Variable used inside SBML models

Species Initial Concentration/Amount

Period circadian protein
0.25 μmol

Period circadian protein
0.25 μmol

Period circadian protein
0.25 μmol

messenger RNA ; RNA
0.1 μmol
Reactions Rate Parameters
Pn => P2 k2*Pn*compartment_0000004 k2=1.3
EmptySet => P0; M ks*M*default ks=0.38
P2 => P1 CYTOPLASM*V4*P2/(K4+P2) V4=2.5; K4=2.0
M => EmptySet Vm*M*CYTOPLASM/(Km+M) Vm=0.65; Km=0.5
P1 => P0 CYTOPLASM*V2*P1/(K2+P1) K2=2.0; V2=1.58
P2 => EmptySet CYTOPLASM*Vd*P2/(Kd+P2) Vd=0.95; Kd=0.2
P1 => P2 CYTOPLASM*V3*P1/(K3+P1) K3=2.0; V3=5.0
P0 => P1 CYTOPLASM*V1*P0/(K1+P0) K1=2.0; V1=3.2
P2 => Pn k1*P2*CYTOPLASM k1=1.9
Curator's comment:
(added: 06 Aug 2007, 13:20:48, updated: 06 Aug 2007, 13:20:48)
Figure 2 reproduced with COPASI 4.1 (build 21)