E-TOXM-21 - Transcription profiling of F344/N rats administered with potassium bromate in the drinking water
Released on 14 November 2006, last updated on 4 June 2014
Ozone has been proposed for water disinfection because it is more efficient than chlorine for killing microbes and results in much lower levels of carcinogenic trihalomethanes than does chlorination. Ozone leads to formation of hypobromous acid in surface waters with high bromine content and forms brominated organic by-products and bromate. The carcinogenicity and chronic toxicity of potassium bromate (KBrO3) [CAS:7758-02-3;CHEBI:32030] was studied in male B6C3F1 mice and F344/N rats to confirm and extend the results of previous work. Mice were treated with 0, 0.08, 0.4, or 0.8 g/L KBrO3 in the drinking water for up to 100 wk, and rats were provided with 0, 0.02, 0.1, 0.2, or 0.4 g/L KBrO3. Animals were euthanatized, necropsied, and subjected to a complete macroscopic examination. Selected tissues and gross lesions were processed by routine methods for light microscopic examination. The present study showed that KBrO3 is carcinogenic in the rat kidney, thyroid, and mesothelium and is a renal carcinogen in the male mouse, KBrO3 was carcinogenic in rodents at water concentrations as low as 0.02 g/L (20 ppm; 1.5 mg/kg/day). These data can be used to estimate the human health risk that would be associated with changing from chlorination to ozonation for disinfection of drinking water.
transcription profiling by array, compound treatment, dose response
Kidney toxicogenomics of chronic potassium bromate exposure in f344 male rats. Geter DR, Ward WO, Knapp GW, Deangelo AB, Rubis JA, Owen RD, Allen JW, Delker DA. :33-52 (2006)
Kidney Toxicogenomics of Chronic Potassium Bromate Exposure in F344 Male Rats. David R. Geter, William O. Ward, Geremy W. Knapp, Anthony B. DeAngelo, Jessica A. Rubis, Russell D. Owen, James W. Allen, and Don A. Delker.