E-TOXM-14 - Transcription profiling of rat liver exposed to methapyrilene - ILSI-HESI Hepatotoxicity Study: methapyrilene
Released on 16 July 2005, last updated on 4 June 2014
This study examines the effects of an hepatotoxicant, Methapyrilene (CAS:91-80-5, CHEBI:6820). on hepatic gene expression in the Sprague-Dawley rat. Rats were treated with two dose levels of the compound for up to seven days. Gene expression profiles were generated using several different microarray platforms for an inter-laboratory comparison.
transcription profiling by array, compound treatment, dose response
Interlaboratory evaluation of rat hepatic gene expression changes induced by methapyrilene. Waring JF, Ulrich RG, Flint N, Morfitt D, Kalkuhl A, Staedtler F, Lawton M, Beekman JM, Suter L.