E-TOXM-13 - Transcription profiling of rat liver exposed to hepatotoxicant clofibrate - ILSI-HESI Hepatotoxicity clofibrate Study
Released on 16 July 2005, last updated on 6 December 2011
This study examines the effects to an hepatotoxicant clofibrate (CAS:637-07-0, CHEBI:3750) on hepatic gene expression in the Sprague-Dawley rat. Rats were treated with two dose levels of the compound for up to seven days. Gene expression profiles were generated using several different microarray platforms for an inter-laboratory comparison.
transcription profiling by array, compound treatment, dose response
Interlaboratory evaluation of rat hepatic gene expression changes induced by methapyrilene. Waring JF, Ulrich RG, Flint N, Morfitt D, Kalkuhl A, Staedtler F, Lawton M, Beekman JM, Suter L.