E-TABM-71 - Transcription profiling of humoral resistance to the CTL after phenotypical and functional study of the resistant clone IGR-HeuR8
Submitted on 20 December 2005, released on 23 January 2006, last updated on 2 May 2014
From a tumoral line IGR-Heu; resulting from a biopsy of the primitive tumour of a patient reached of a bronchial cancer not with small cells (NSCLC); we established; by successive co-cultures of this line with the autologous CTL (clone T H161); a resistant line to the cytotoxic lysis induced by H161 (IGR-HeuR8 line). This resistant line was then cloned by limiting dilutions and a resistant clone was obtained (tumoral clone IGR-HeuR8). The goal of this study is to define profiles of genetic expression of the tumoral resistance to the CTL after phenotypical and functional study of the resistant clone IGR-HeuR8.
transcription profiling by array, compound treatment, disease state
Audrey Kauffmann <Philippe.DESSEN@gustaveroussy.fr>, Abdelali Jalil, Catherine Gaudin, Catherine Richon, Fathia Mami-Chouaib and Salem Chouaib, Georges Bismuth, Graca Raposo, Isabelle Vergnon, Jean Dausset, Jérôme Galon, Oliver Caroll, Peter Van Endert, Soraya Abouzahr
Identification of target actin content and polymerization status as a mechanism of tumor resistance after cytolytic T lymphocyte pressure. Abouzahr, Soraya; Bismuth, Georges; Gaudin, Catherine; Caroll, Oliver; Van Endert, Peter; Jalil, Abdelali; Dausset, Jean; Vergnon, Isabelle; Richon, Catherine; Kauffmann, Audrey; Galon, Jerome; Raposo, Graca; Mami-Chouaib, Fathia; Chouaib, Salem. Proc Natl Acad Sci U S A 103(5):1428 (2006), Europe PMC 16432193