E-TABM-42 - Transcription profiling of human chronic lymphocytic leukemia miRNA expression validation
Released on 27 October 2005, last updated on 27 March 2012
MicroRNA expression profiles can distinguish normal B cells from malignant B cells in chronic lymphocytic leukemia (CLL). We investigated whether microRNA profiles are associated with known prognostic factors in CLL. We evaluated the microRNa expression profiles of 94 samples of CLL cells for which ZAP-70 expression; mutations in the rearranged IgVH gene; and the time from diagnosis to initial treatment were known. We also investigated the presence of abnormalities in the genomic sequence of 42 microRNA genes.
transcription profiling by array, disease state
George Calin, Manuela Ferracin, Amelia Cimmino, Carlo M. Croce, Chang-gong Liu, Cinzia Sevignani, Claudia Roldo, Flavia Pichiorri, George Adrian Calin, Gianpiero Di Leva, Hansjuerg Alder, Laura Rassenti, Marilena V. Iorio, Masayoshi Shimizu, Massimo Negrini, Muller Fabbri, Nuretin Ilfer Sever, Ramiro Garzon, Rodolfo Iuliano, Rosa Visone, Stefano Volinia, Sylwia Wojcik, Thomas J. Kipps, Tiziana Palumbo
A MicroRNA Signature Associated with Prognosis and Progression in chronic lymphocytic leukemia. George Adrian Calin; Manuela Ferracin; Amelia Cimmino; Gianpiero Di Leva; Masayoshi Shimizu; Sylwia Wojcik; Marilena V. Iorio; Rosa Visone; Nuretin Ilfer Sever; Muller Fabbri; Rodolfo Iuliano; Tiziana Palumbo; Flavia Pichiorri; Claudia Roldo; Ramiro Garzon; Cinzia Sevignani; Laura Rassenti; Hansjuerg Alder; Stefano Volinia; Chang-gong Liu; Thomas J. Kipps; Massimo Negrini; Carlo M. Croce. N Engl J Med 353(17):21-29 (2005)