E-SMDB-3750 - Transcription profiling of human BCR-ABL positive and negative adult Acute Lymphoblastic Leukemia samples
Submitted on 8 March 2007, released on 23 May 2007, last updated on 27 March 2012
A set of 37 BCR-ABL positive (21 and 16 of which expressed p185 and p210, respectively) and 17 BCR-ABL negative adult ALL specimens from MRC UKALLXII/ECOG E2993 intergroup study. Gene expression profiling was performed using the 3DNA Array 900 Expression Array Detection Kit (Genisphere, Hatfield, PA), according to the manufacturers instructions. Universal Human Reference RNA (Stratagene, La Jolla, CA) was used as a reference RNA. The results provide insights into molecular mechanisms and pathways associated with BCR-ABL oncogenesis.
transcription profiling by array, disease state
Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias. Juric D, Lacayo NJ, Ramsey MC, Racevskis J, Wiernik PH, Rowe JM, Goldstone AH, O'Dwyer PJ, Paietta E, Sikic BI. Juric D, et al. (2007) J Clin Oncol (): (2007-03-05), Europe PMC 17312329