E-SMDB-1819 - Transcription profiling of human healthy peripheral blood from different individuals
Released on 5 October 2005, last updated on 12 October 2011
We carried out a survey of the variation in gene expression patterns in the blood of healthy individuals, by using cDNA microarrays. Our results revealed a surprising consistency in these patterns, but also evidence of distinct patterns of interindividual and temporal variation. Some features of variation in the expression patterns were associated with differences in the cellular composition of the blood sample, with gender, age, and time of day. These results expand our understanding of human variation and hematological physiology and provide a genome-wide molecular portrait of a healthy human tissue.
transcription profiling by array, individual comparison
Individuality and variation in gene expression patterns in human blood. Whitney AR, Diehn M, Popper SJ, Alizadeh AA, Boldrick JC, Relman DA, Brown PO.