E-SGRP-7 - Transcription profiling of Salmonella enterica serotype SL1344 wildtype, pSf-R27sfh and pSf-R27 at stationary and exponential growth phases, to investigate the role of the Sfh protein encoded by transmissible plasmids and involved in human typhoid
Released on 15 January 2007, last updated on 2 May 2014
Salmonella enterica serotype Typhimurium
The Sfh protein is encoded by self-transmissible plasmids involved in human typhoid and is closely related to the global regulator H-NS. We have found that Sfh provides a stealth function that allows the plasmids to be transmitted to new bacterial hosts with minimal effects on their fitness. Introducing the plasmid without the sfh gene imposes a mild H-NS- phenotype and a severe loss of fitness due to titration of the cellular pool of H-NS by the A+T-rich plasmid. This stealth strategy seems to be used widely to aid horizontal DNA transmission and has important implications for bacterial evolution.
transcription profiling by array, strain or line
An H-NS-like Stealth Protein Aids Horizontal DNA Transmission in Bacteria. Marie Doyle, Maria Fookes, Al Ivens, Michael W. Mangan, John Wain, and Charles J Dorman.