E-MTAB-815 - DNA methylation profiling of human adrenocortical tumors (ACTs)

Released on 5 October 2012, last updated on 2 May 2014
Homo sapiens
Samples (135)
Array (1)
Protocols (6)
A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net) | Transcriptome analysis led to the unsupervised classification of carcinomas in two groups, associated with different outcomes {de Reynies, 2009 ; Giordano, 2009}. Subsequently, we have shown that unsupervised clustering further classified the tumors of the poor prognosis group in three different subgroups, two of them harbouring a cardinal molecular alteration {Ragazzon, 2010}. One is associated with p53 inactivation, the second with ?-catenin activation. No molecular defect has been identified in the third group so far. The aim is to describe the genome-wide methylome of adrenocortical tumors, and to assess the link with previously established molecular classifications. Experimental design: Genome-wide methylation patterns of 84 adenomas and 51 carcinomas were obtained with the Infinium HumanMethylation27 beadchip (Illumina). | Submitter : Olivia Barreau <olivia.barreau@inserm.fr> | Project leader : Jerome Bertherat <jerome.bertherat@inserm.fr>
Experiment types
methylation profiling by array, DNA methylation array
Identification of a CpG Island Methylator Phenotype in Adrenocortical Carcinomas. Olivia Barreau, Guillaume Assie , Hortense Wilmot-Roussel, Bruno Ragazzon, Camille Baudry, Karine Perlemoine, Fernande Rene-Corail, Xavier Bertagna, Bertrand Dousset, Nadim Hamzaoui, Frederique Tissier, Aurelien de Reynies, Jerome Bertherat. FIX:Journal of Clinical Endocrinology & Metabolism 98(1) (2013), Europe PMC 23093492
Investigation descriptionE-MTAB-815.idf.txt
Sample and data relationshipE-MTAB-815.sdrf.txt
Raw data (1)E-MTAB-815.raw.1.zip
Processed data (1)E-MTAB-815.processed.1.zip
Array designA-GEOD-8490.adf.txt