E-MTAB-7931 - Baseline expression of symptomatic and asymptomatic subjects after YF17D vaccination in Trial 2
Submitted on 1 September 2018, last updated on 11 May 2019, released on 11 May 2019
This study investigates how the baseline expression level of genes impact symptomatic outcome of flaviviral infection. Before given the YF17D vaccine, whole blood was extracted into tempus tubes from vaccinated subjects. Thereafter, the subjects were assessed if they experienced adverse events (or symptoms). 35 subjects (n=12 symptomatic, n=23 asymptomatic) were processed according to manufacturer's protocol. Transcript expression was then evaluated by nCounter RNA Cancer Metabolism (#VRXC-CM1-12) or a custom Unfolded Protein Response codeset and its respective probesets.
transcription profiling by array, disease state design
Metabolic perturbations and cellular stress underpin susceptibility to symptomatic yellow fever infection. Kuan Rong Chan, Esther Shuyi Gan, Candice Yuen Yue Chan, Cui Liang, John Zhong Heng Low, Summer Li-Xin Zhang, Eugenia Ziying Ong, Ashwin Bhatta, Limin Wijaya, Yie Hou Lee, Jenny Guek-Hong Low, Eng Eong Ooi.