E-MTAB-788 - Transcription profiling by array of human breast cancer cell line MCF-7 treated with estradiol
Released on 25 October 2011, last updated on 2 May 2014
The Estrogen Receptor cofactors SRC1 (NCOA1, KAT13A), SRC2 (NCOA2, GRIP1, TIF2, KAT13C) , SRC3 (NCOA3, AIB1, KAT13B, Rac3) , CBP and p300 are assessed for their genome-wide chromatin binding capacities in the breast cancer cell line MCF7. To determine the Estrogen Receptor dependency of interactions, experiments were performed in the absence of hormone and after Estradiol treatment. In addition, the data were compared with Estrogen Receptor ChIP-seq data from the same timepoint of Estradiol treatment.
transcription profiling by array, co-expression, compound treatment, replicate
Oestrogen receptor-co-factor-chromatin specificity in the transcriptional regulation of breast cancer. Zwart W, Theodorou V, Kok M, Canisius S, Linn S, Carroll JS. EMBO J (2011)