E-MTAB-784 - Transcriptome profiling of a backcross between experimental autoimmune encephalomyelitis (EAE)-susceptible DA and EAE-resistant PVG rat strains to identify expression quantitative trait loci
Released on 10 August 2013, last updated on 2 May 2014
The aim of the experiment is to characterize the genetics and mechanisms of the inflammatory response after induction of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, by studying the genome wide expression in the spleen in late disease. A backcross was created between EAE-susceptible DA and EAE-resistant PVG rats. At day 35 after induction of EAE with myelin oligodendrocyte glycoprotein (MOG) in these rats, spleens were taken for transcriptional profiling.
transcription profiling by array, ex vivo, individual genetic characteristics
Combining genetic mapping with genome-wide expression in experimental autoimmune encephalomyelitis highlights a gene network enriched for T cell functions and candidate genes regulating autoimmunity. Melanie Thessen Hedreul; Steffen Möller; Pernilla Stridh; Yask Gupta; Alan Gillett; Amennai Daniel Beyeen; Johan Öckinger; Sevasti Flytzani; Margarita Diez; Tomas Olsson; Maja Jagodic. Hum Mol Genet 22(24):4952 (2013), Europe PMC 23900079
Combining genetic mapping with genome-wide expression in experimental autoimmune encephalomyelitis highlights a gene network enriched for T cell functions and candidate genes regulating autoimmunity. Thessen Hedreul M, Möller S, Stridh P, Gupta Y, Gillett A, Daniel Beyeen A, Öckinger J, Flytzani S, Diez M, Olsson T, Jagodic M. :4952-4966 (2013), Europe PMC 23900079