E-MTAB-7765 - RNAseq of the small intestine of mice 6 days after they were transplanted with either wildtype allogeneic T cells or glucocorticoid-resistant allogeneic T cells (mouse model of acute graft-versus-host disease
Submitted on 14 August 2017, last updated on 12 March 2019, released on 12 March 2019
Given that mice transplanted with glucocorticoid-resistant T cells display more severe disease symptoms, the idea was that an RNA-seq comparison between mice transplanted with either wildtype or glucocorticoid-resistant T cells could yield genes involved in disease progression and potential therapeutic targets.
RNA-seq of coding RNA, genetic modification design
Glucocorticoid resistance of allogeneic T cells alters the gene expression profile in the inflamed small intestine of mice suffering from acute graft-versus-host disease. Hu Li, Tina K. Kaiser, Marina Borschiwer, Hanibal Bohnenberger, Fred Lühder, Lutz Walter, Ralf Dressel, Sebastiaan H. Meijsing and Holger M. Reichardt.