E-MTAB-7484 - Microarray of human primary CD16+ monocytes treated with fractalkine (CX3CL1) against untreated controls
Last updated on 8 February 2019, released on 8 February 2019
This experiment is a part of the larger study on angiotensin II role in the upregulation of the CX3CL1 expression and its release in human first trimester placenta. CX3CL1 (or fractalkine) is chemokine involved in the pathogenesis of hypertension, which can be secreted by trophoblasts, initiating the cross talk with monocytes. Thus, we performed the microarray experiment to study the effects of recombinant human CX3CL1 on the transcriptome of human primary monocytes.
transcription profiling by array, case control design
Placental CX3CL1 is Deregulated by Angiotensin II and Contributes to a Pro-Inflammatory Trophoblast-Monocyte Interaction. Olivia Nonn, Jacqueline Güttler, Désirée Forstner, Sabine Maninger, Julianna Zadora, András Balogh, Alina Frolova, Andreas Glasner, Florian Herse, Martin Gauster. Int J Mol Sci 3(20):641 (2019)