E-MTAB-7428 - SUMOylation promotes survival and integration of neural stem cell grafts in stroke
Submitted on 7 July 2016, last updated on 11 April 2019, released on 11 April 2019
In this study we sought to determine the effect of overexpressing the SUMOylation E2 conjugase Ubc9 on the response of murine Neural Stem Cells (NSCs) to oxygen-glucose-deprivation and restoration of oxygen/glucose (OGD/ROG). We established stably-expandable lines of NSCs from the subventricular zones (SVZ) of adult wild-type mice (WT NSCs) and Ubc9-overexpressing mice (Ubc9 NSCs) and profiled their transcriptional changes in response to OGD/ROG as well as in response to differentiation.
transcription profiling by array, case control design