E-MTAB-7416 - Transcriptomics study on the effect of alternative oxidase expression in Bcs1l mutant (S78G) mice (Mus musculus)

Submitted on 16 January 2017, released on 16 November 2018, last updated on 21 November 2018
Mus musculus
Samples (72)
Protocols (4)
The dataset contains 72 RNA-seq samples obtained from adult (P150) C57BL/6JCrl mice. Samples are from total heart, liver and kidney tissue. Four different genotypes are included in the data: 1) wild type, 2) transgenic Ciona intestinalis AOX in Rosa26 locus (Szibor et al. 2017, DOI: 10.1242/dmm.027839), 3) respiratory chain complex III deficient Bcs1lp.S78G knock-in mice (a GRACILE syndrome patient mutation, Leveen et al. 2011, DOI: 10.1002/hep.24031) and 4) a cross between the AOX transgenic and Bcs1lp.S78G mice (Rajendran et al. EMBO Mol Med. In press).
Experiment types
RNA-seq of coding RNA, genetic modification design, genotype design
Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy. Jayasimman Rajendran, Janne Purhonen, Saara Tegelberg, Olli-Pekka Smolander, Matthias Mörgelin, Jan Rozman, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabe de Angelis, Petri Auvinen, Eero Mervaala, Howard T. Jacobs, Marten Szibor, Vineta Fellman, Jukka Kallijärvi.
Exp. designProtocolsVariablesProcessedSeq. reads
Investigation descriptionE-MTAB-7416.idf.txt
Sample and data relationshipE-MTAB-7416.sdrf.txt