E-MTAB-7103 - RNA-seq of equine and canine mammary stem cells treated with DMBA
Submitted on 30 March 2017, last updated on 1 August 2018, released on 31 August 2018
Canis lupus familiaris, Equus caballus
Whereas canines are susceptible to mammary cancer at a frequency similar to humans, equines are largely resistant to the disease. We treated mammary stem cells from both species with the chemical carcinogen, DMBA, and found that equine cells are significantly more susceptible to treatment. These RNA-seq results represent samples from three individuals of dogs and horses in order to reveal transcriptional differences in response to treatment that may explain the phenotypic differences we observed.
RNA-seq of coding RNA, compound treatment design