E-MTAB-6878 - JAK2V617F mutant HSC microarray

Status
Submitted on 20 March 2014, last updated on 6 August 2018, released on 6 August 2018
Organism
Mus musculus
Samples (9)
Array (1)
Protocols (6)
Description
Mutant JAK2V617F is found in majority of patients with myeloproliferative neoplasm. While heterozygous JAK2V617F induced an ET-like phenotype, JAK2V617F homozygosity drives an severe PV-like phenotype in knock-in mice. HSCs from mice with homozygous JAK2V617F expression show impaired self-renewal in transplants. To understand the molecular mechanisms involved this HSC functional defect, microarray was performed on isolated LT-HSCs from mice expressing wildtype, heterozygous and homozygous expression of mutant JAK2.
Experiment types
transcription profiling by array, genotype design
Contacts
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-MTAB-6878.idf.txt
Sample and data relationshipE-MTAB-6878.sdrf.txt
Raw data (1)E-MTAB-6878.raw.1.zip
Processed data (1)E-MTAB-6878.processed.1.zip
Array designA-MEXP-1175.adf.txt
Links