E-MTAB-6478 - Transcription profiling of peripheral blood monocyte derived macrophages treated or not with synthetic REVERB ligand GSK-4112
Submitted on 18 February 2010, last updated on 13 May 2019, released on 13 May 2019
Circadian biology regulates inflammatory responses in mice via the clock protein REVERBα, resulting in altered mortality and morbidity. The influence of this immune-modulation pathway in humans is unclear, but may affect outcomes after transplant. We sought to determine whether the circadian clock affects primary graft dysfunction after lung transplantation, and the role of the clock protein REVERBα. In this study we investigated the action of a synthetic REVERB ligand, (GSK4112) in human monocyte-derived macrophages.
transcription profiling by array, dose response design
Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation. Cunningham PS, Maidstone R, Durrington HJ, Venkateswaran RV, Cypel M, Keshavjee S, Gibbs JE, Loudon AS, Chow CW, Ray DW, Blaikley JF. 74(4):413-416 (2019), PMID:30301818