E-MTAB-6397 - DNA-METHYLATION - Integrative multi-omics survey of effects carbon-based engineered nanomaterials on lung derived cell-lines
Submitted on 2 March 2016, last updated on 19 May 2018, released on 19 May 2018
In this study we exposed three human lung derived cell lines to sublethal dosages of nanomaterials for a limited amount of time. For the first time, we assessed the simultaneous effects of nanomaterials exposure on three distinct molecular layers along with their interactions in the determination of the MOA of 10 carbon based nanomaterials. By performing an integrative analysis we provide here a complete picture of the interaction between regulatory factors (DNA methylation and miRNAs) and mRNA deregulation subsequent to exposing different cellular systems to different nanomaterials.
transcription profiling by array, cell type comparison design, compound treatment design