E-MTAB-6074 - Transcription profiling by array of adult mouse lung exposed to room air (control) or 100% oxygen between postnatal days 0 to 4
Submitted on 19 August 2008, last updated on 20 September 2017, released on 1 January 2018
It is unclear why preterm birth increases risk of cardiovascular disease later in life. Studies in mice indicate excess oxygen used to treat preterm infants causes pulmonary hypertension, cardiac failure, and shortens lifespan. We previously reported neonatal hyperoxia causes pulmonary hypertension in aged mice as defined pathologically by pulmonary capillary rarefaction, dilation of pulmonary arterioles and veins, right ventricular hypertrophy, and reduced lifespan. Here, affymetrix gene arrays were used to identify early transcriptional changes in lungs of young adult mice exposed to room air or 100% oxygen between postnatal days 0-4.
transcription profiling by array, disease state design, injury design