E-MTAB-5934 - Transcription profiling by array of B lymphoblasts derived from either control donors or patients with loss of function mutations in TTC7A
Submitted on 19 July 2017, last updated on 7 September 2017, released on 19 July 2018
As a member of the tetratricopeptide repeat (TPR) family, TTC7A is expected to mediate a wide range of interactions with proteins within several molecular complexes. TTC7A is expressed in hematopoietic and epithelial cells however its cellular function remains poorly understood. In this regard we performed a global transcriptional profiling by using HTA-2 microarrays on 4 healthy donors and 6 patients carrying distinct TTC7A mutations.
transcription profiling by array, case control design