E-MTAB-5557 - Time course RNA-seq of Mycobacterium tuberculosis exposed to nitric oxide
Submitted on 22 February 2017, last updated on 29 August 2017, released on 29 August 2017
Mycobacterium tuberculosis H37Rv
Mycobacterium tuberculosis is an intracellular human pathogen with the ability to resist and adapt to many adverse conditions it encounters upon infection. Among these, overcoming the production of nitric oxide by macrophages could be key for M. tuberculosis success. We have challenged M. tuberculosis with a sub-lethal concentration of nitric oxide and followed the transcriptomic response through RNA-seq for 48 hours.
RNA-seq of coding RNA, stimulus or stress design
Delayed effects of transcriptional responses in Mycobacterium tuberculosis exposed to nitric oxide suggest other mechanisms involved in survival. Cortes T, Schubert OT, Banaei-Esfahani A, Collins BC, Aebersold R, Young DB. Scientific Reports 7(1):8208 (2017), PMID:28811595