E-MTAB-5277 - Response of Candida albicans to taurocholate
Submitted on 7 April 2014, released on 15 February 2017, last updated on 20 February 2017
Presence of taurocholate (TC), a constituent of bile, confers resistance of Candida albicans to antifungals like Caspofungin and Amphotericin B. Transcriptional profiles in presence and absence of TC were compared to determine whether an upregulation of known resistance genes is responsible for this effect. No upregulation was found, and the resistance seemed to be rather based on a direct interaction of TC with the antifungals.
transcription profiling by array, compound treatment design
Encapsulation of Antifungals in Micelles Protects Candida albicans during Gall-Bladder Infection. Hsieh SH, Brunke S, Brock M. 8:117 (2017), PMID:28203228