E-MTAB-5109 - Methylome profiling of glioblastoma biopsies obtained by neuro-navigation in four distinct areas for 10 patients (necrotic zone, tumor zone, interface, and peripheral brain zone)

Status
Released on 19 September 2016, last updated on 20 September 2016
Organism
Homo sapiens
Samples (23)
Array (1)
Protocols (7)
Description
We classified samples and deciphered a key genes signature of intratumor heterogeneity by Principal Component Analysis and Weighted Gene Co-expression Network Analysis. We provide a signature of key cancer-heterogeneity genes highly associated with the intratumor spatial gradient and show that it is enriched in genes with correlation between methylation and expression levels.
Experiment types
methylation profiling by array, cell type comparison design
Contact
Citations
From the core to beyond the margin: a genomic picture of glioblastoma intratumor heterogeneity. Aubry M, de Tayrac M, Etcheverry A, Clavreul A, Saikali S, Menei P, Mosser J. , PMID:25940437
Correction: From the core to beyond the margin: a genomic picture of glioblastoma intratumor heterogeneity. Aubry M, de Tayrac M, Etcheverry A, Clavreul A, Saikali S, Menei P, Mosser J. :67685 (2016), PMID:28049185
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-MTAB-5109.idf.txt
Sample and data relationshipE-MTAB-5109.sdrf.txt
Raw data (1)E-MTAB-5109.raw.1.zip
Processed data (1)E-MTAB-5109.processed.1.zip
Array designA-GEOD-8490.adf.txt